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研究

研究業績

2015年

  1. Anraku M, Tabuchi R, Ifuku S, Ishiguro T, Iohara D, Hirayama F.
    Surface-Deacetylated Chitin Nano-Fiber/Hyaluronic Acid Composites as Potential Antioxidative Compounds for Use in Extended-Release Matrix Tablets.
    Int J Mol Sci. 2015 16(10):24707-17.
  2. Nishida K, Watanabe H, Ogaki S, Kodama A, Tanaka R, Imafuku T, Ishima Y, Chuang VT, Toyoda M, Kondoh M, Wu Q, Fukagawa M, Otagiri M, Maruyama T.
    Renoprotective effect of long acting thioredoxin by modulating oxidative stress and macrophage migration inhibitory factor against rhabdomyolysis-associated acute kidney injury.
    Sci Rep. 2015 5:14471.
  3. Taguchi K, Yamasaki K, Seo H, Otagiri M.
    Potential Use of Biological Proteins for Liver Failure Therapy.
    Pharmaceutics. 2015 7(3):255-74.
  4. Lu J, Yoshimura K, Goto K, Lee C, Hamura K, Kwon O, Tamanoi F.
    Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells.
    PLoS One. 2015 10(9):e0137595.
  5. Hashimoto M, Taguchi K, Ogaki S, Watanabe H, Kinoshita M, Nishikawa K, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.
    Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia.
    J Pharm Sci. 2015 104(11):3968-76.
  6. Ogaki S, Taguchi K, Maeda H, Watanabe H, Ishima Y, Otagiri M, Maruyama T.
    Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock.
    Biochem Pharmacol. 2015 97(3):310-9.
  7. Enoki Y, Ishima Y, Tanaka R, Sato K, Kimachi K, Shirai T, Watanabe H, Chuang VT, Fujiwara Y, Takeya M, Otagiri M, Maruyama T.
    Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury.
    PLoS One. 2015 10(6):e0130248.
  8. Anraku M, Shintomo R, Taguchi K, Kragh-Hansen U, Kai T, Maruyama T, Otagiri M.
    Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants.
    Life Sci. 2015 134:36-41.
  9. Kadowaki D, Anraku M, Sakaya M, Hirata S, Maruyama T, Otagiri M.
    Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury.
    Clin Exp Nephrol. 2015 19(6):1007-14.
  10. Anraku M, Hiraga A, Iohara D, Pipkin JD, Uekama K, Hirayama F.
    Slow-release of famotidine from tablets consisting of chitosan/sulfobutyl ether β-cyclodextrin composites.
    Int J Pharm. 2015 487(1-2):142-7.
  11. Taguchi K, Hashimoto M, Ogaki S, Watanabe H, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.
    Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen ホウ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model.
    J Pharm Sci. 2015 104(9):3084-91.
  12. Watanabe H, Miyamoto Y, Enoki Y, Ishima Y, Kadowaki D, Kotani S, Nakajima M, Tanaka M, Matsushita K, Mori Y, Kakuta T, Fukagawa M, Otagiri M, Maruyama T.
    p-Cresyl sulfate, a uremic toxin, causes vascular endothelial and smooth muscle cell damages by inducing oxidative stress.
    Pharmacol Res Perspect. 2015 3(1):e00092.
  13. Taguchi K, Tokuno M, Yamasaki K, Kadowaki D, Seo H, Otagiri M.
    Establishment of a model of acetaminophen-induced hepatotoxicity in different weekly-aged ICR mice.
    Lab Anim. 2015 49(4):294-301.
  14. Umezaki Y, Iohara D, Anraku M, Ishitsuka Y, Irie T, Uekama K, Hirayama F.
    Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.
    Biomaterials. 2015 45:115-23.
  15. Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VT, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T.
    Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models.
    J Pharmacol Exp Ther. 2015 352(2):244-57.
  16. Y. Inoue, N. Sekiya, M. Yamamoto, D. Iohara, F. Hirayama, K. Uekama.
    Formation of Ternary Inclusion Complex of Limaprost with α- and β-Cyclodextrins in Aqueous Solution.
    Chem. Phram. Bull., 63, 318-325 (2015).
  17. M. Anraku, D. Iohara, A. Hiraga, K. Uekama, S. Ifuku, J. D. Pipkin and F. Hirayama.
    Formation of Elastic Gels from Surface-deacetylated Chitin Nanofibers Reinforced with Sulfobutyl Ether β-Cyclodextrin.
    Chem. Lett., 44, 285-287(2015).
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