メニュー

研究

研究業績

2014年

  1. Tanaka R, Ishima Y, Enoki Y, Kimachi K, Shirai T, Watanabe H, Chuang VT, Maruyama T, Otagiri M.
    Therapeutic impact of human serum albumin-thioredoxin fusion protein on influenza virus-induced lung injury mice.
    Front Immunol. 2014 5:561.
  2. Anraku M, Tanaka M, Hiraga A, Nagumo K, Imafuku T, Maezaki Y, Iohara D, Uekama K, Watanabe H, Hirayama F, Maruyama T, Otagiri M.
    Effects of chitosan on oxidative stress and related factors in hemodialysis patients.
    Carbohydr Polym. 2014 112:152-7.
  3. Anraku M, Hiraga A, Iohara D, Uekama K, Tomida H, Otagiri M, Hirayama F.
    Preparation and antioxidant activity of PEGylated chitosans with different particle sizes.
    Int J Biol Macromol. 2014 70:64-9.
  4. Ogaki S, Taguchi K, Watanabe H, Ishima Y, Otagiri M, Maruyama T.
    Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats.
    J Pharm Sci. 2014 103(7):2199-2206.
  5. Yin H, Fang J, Liao L, Nakamura H, Maeda H.
    Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease.
    J Control Release. 2014 187:14-21.
  6. Ishima Y, Fang J, Kragh-Hansen U, Yin H, Liao L, Katayama N, Watanabe H, Kai T, Suenaga A, Maeda H, Otagiri M, Maruyama T.
    Tuning of poly-S-nitrosated human serum albumin as superior antitumor nanomedicine.
    J Pharm Sci. 2014 103(7):2184-2188.
  7. Nagao S, Taguchi K, Sakai H, Tanaka R, Horinouchi H, Watanabe H, Kobayashi K, Otagiri M, Maruyama T.
    Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis.
    Biomaterials. 2014 35(24):6553-62.
  8. Kouno Y, Anraku M, Yamasaki K, Okayama Y, Iohara D, Ishima Y, Maruyama T, Kragh-Hansen U, Hirayama F, Otagiri M.
    N-acetyl-l-methionine is a superior protectant of human serum albumin against photo-oxidation and reactive oxygen species compared to N-acetyl-L-tryptophan.
    Biochim Biophys Acta. 2014 1840(9):2806-12.
  9. Sato H, Chuang VT, Yamasaki K, Yamaotsu N, Watanabe H, Nagumo K, Anraku M, Kadowaki D, Ishima Y, Hirono S, Otagiri M, Maruyama T.
    Differential effects of methoxy group on the interaction of curcuminoids with two major ligand binding sites of human serum albumin.
    PLoS One. 2014 9(2):e87919.
  10. Ishima Y, Kragh-Hansen U, Maruyama T, Otagiri M.
    Poly-s-nitrosated albumin as a safe and effective multifunctional antitumor agent: characterization, biochemistry and possible future therapeutic applications.
    Biomed Res Int. 2013 2013:353892.
  11. Nagumo K, Tanaka M, Chuang VT, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T.
    Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases.
    PLoS One. 2014 9(1):e85216.
  12. Kodama A, Watanabe H, Tanaka R, Kondo M, Chuang VT, Wu Q, Endo M, Ishima Y, Fukagawa M, Otagiri M, Maruyama T.
    Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity.
    Biochim Biophys Acta. 2014 1840(3):1152-62.
  13. Y. Inoue, N. Sekiya, K. Katayama, S. Narutaki, M. Yamamoto, D. Iohara, F. Hirayama, K. Uekama.
    Stabilizing Effect of β-Cyclodextrin on Limaprost, a PGE1 Derivative, in Limaprost Alfadex Tablets (Opalmon®) in Highly Humid Conditions.
    Chem. Pharm. Bull., 62, 786-792 (2014).
  14. H. Aldawsari, A. Altaf, Z. M. Banjar, M. Okubo, D. Iohara, M. Anraku, F. Hirayama and K. Uekama.
    Combined Use of Cyclodextrins and Hydroxypropylmethylcellulose Stearoxy Ether (Sangelose®) for the Preparation of Orally Disintegrating Tablets of Type-2 Antidiabetes Agent Glimepiride.
    J. Inclusion Phenom. Macrocyclic Chem., 80, 61-67 (2014).
  15. Altaf, H. Aldawsari, Z. M. Banjar, D. Iohara, M. Anraku, K. Uekama, F. Hirayama.
    Potential Use of C60/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer.
    Int. J. Photoenergy., Article ID 570506 (2014).
  16. 安楽 誠
    血清アルブミンの酸化ストレス解明と酸化ストレス関連疾患への展開
    薬学雑誌, 134,(9), 973-979 (2014).
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