研究業績

Publication

2005

1.       K. Greish, A. Nagamitsu, J. Fang and H. Maeda: Copoly (styrene-maleic-acid)-pirarubicin micelles: high tumor targeting efficacy with low toxicity. Bioconj. Chem.,16, 230-236 (2005)

2.       D. Wakamatsu, S. Morimura, T. Sawa, K. Kida, C. Nakai and H. Maeda: Isolation, identification, and structure of a potent alkyl-peroxyl radical scavenger in crude oil, canolol. Biosci., Biotechnol., Biochem., 69, 1568-1574 (2005)

3.       Y. Miyamoto, T. Akaike, S. Kawabata, T. Akuta, C. Taruki, J. Yoshitake, F. Ota, S. Hamada, H. Igarashi, and H. Maeda: Degradation of bradykinin by a metallo-endopeptidase from Streptococcus pyogenes. Infect. Immun., (in revising process, 2005)

4.       K. Greish, I. Sanada, A. Saad, E. Hasanin, M. Kawasuji, F. Kawano and H. Maeda: Protective effect of melatonin on human peripheral blood hematopoeitic stem cells against doxorubicin cytotoxicity. Anticancer Res., 25, 4245-4248 (2005)

5.       M. Mayerhofer, K. J. Aichberger, S. Florian, M.T. Krauth, S. Derdak, H. Esterbauer, O. Wagner, W. F. Pickl, E. Selzer, M.W. Deininger, B. J. Druker, K. Greish, H. Maeda, C. Sillaber, and P. Valent.  The heme oxygenase-1-targeting compound PEG-ZnPP inhibits growth of imatinib-resistant BCR/ABL-transformed cells. Blood, 104, 1986 (2005)

[Monograph]

6.       H. Maeda, J. Fang and T. Sawa: Factors and mechanism of “EPR” effect and clinical outlook of SMANCS. In Cancer Chemoprevention and Drug Therapy of the New Millenium (eds. R. Han and Y. Sun), People’s Military Medical Press, Beijing, Chap. 13, 197-212 (2005)

7.       H. Maeda, J. Fang and T. Sawa: Use of lipiodol as carrier in cancer target chemotherapy. In Cancer Chemoprevention and Drug Therapy of the New Millennium (eds. R. Han and Y. Sun), People’s Military Medical Press, Beijing, Chap. 14, 213-227 (2005)

2006

8.       H. Maeda, K. Greish, and J. Fang: EPR effect and polymeric drugs: challenge for a paradigm shift for cancer chemotherapy in the 21^st century. Adv. Polym. Sci., 193, 103-121(2006)

9.       A. K. Iyer, G. Khaled, J. Fang and H. Maeda: Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discovery Today, 11, 812-818 (2006)

[Monograph]

10.     K. Greish, A.K. Iyer, J. Fang, M. Kawasuji, and H. Maeda: Enhanced permeability and retention (EPR) effect and tumor-selective delivery of anticancer drugs. In Delivery of Protein and Peptide Drugs in Cancer (V. Torchilin), Imperial College Press, London, 37-52 (2006)

2007

11.    M. Regehly, K. Greish, F. Rancan, H. Maeda, F. Böhm and B. Röder: Water-soluble polymer conjugated of ZnPP for photodynamic tumour therapy. Bioconj. Chem., 18, 494-499 (2007)

12.    A. K. Iyer, K. Greish, J. Fang, R. Murakami and H. Maeda: High-loading nanosized micelles of copoly(styrene–maleic acid)–zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor. Biomaterials, 28, 1871-1881(2007)

13.    R. Kondo, M. Mayerhofer, K. V. Gleixner, A. Vales, A. Gruze, W. F. Pickl, P. Samorapoompichit, K. Greish, M. T. Krauth, K. J. Aichberger, H. Esterbauer, C. Sillaber, H. Maeda, P. Valent.  Identification of heat shock protein 32 (Hsp32) as a novel KIT D816V-inducible survival factor and target in neoplastic mast cells. Blood, 110, 2, 661-669 (2007)

14.     J. Fang, H. Nakamura & A.K. Iyer. Tumor-targeted induction of oxystress for cancer therapy. J Drug Targeting, 15, 475-486, 2007

15.  J. Daruwella, K. Greish, M. Nikfarjam, I. Millar, C. Malcontenti-Wilson, A. K. Iyer, C. Christophi: Evaluation of the effect of SMA-pirarubicin micelles on colorectal cancer liver metastases and of hyperbaric oxygen in CBA mice. J Drug Targeting, 15, 487-495, 2007

16.    A K Iyer, K. Greish, T. Seki, S. Okazaki, J. Fang, K. Takeshita and H. Maeda. Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation. J Drug Targeting

17.    K. Greish and H. Maeda. Enhanced permeability and retention of macromolecular drugs in solid tumors, a royal gate for targeted anticancer nanomedicines. J Drug Targeting, 15, 457-464, 2007

2008

18..     M. Mayerhofer, K. V. Gleixner, G. Hörmann, K. Sonneck, K. J. Aichberger, R. G. Ott, K. Greish, H. Nakamura, S. Derdak, P. Samorapoompichit, W. F. Pickl, V. Sexl, H. Esterbauer, C. Sillaber, H. Maeda, P. Valent.  Targeting of heat shock protein 32 (Hsp32) / heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib. Blood, 111, 2200-2210 (2008)

19.  X. Cao, T. Tsukamoto, T. Seki, H. Tanaka, S. Morimura, L. Cao, T. Mizoshita, H. Ban, T. Toyoda, H. Maeda and M. Tatematsu. 4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils.  Int J Cancer, 122, 1445-1454 (2008)

20.  J. Fang, D. Deng, H. Nakamura, T. Akuta, H. Quin, A. Iyer, K. Greish, H. Maeda, Oxystress indusing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase. Int. J. Cancer 122 1135-1144 (2008)