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@ 1. H. Maeda, K. Kumagai and N. Ishida: characterization of neo-carzinostatin. J. Antibiotics, 19, 254-259 (1966) 2. K. Kumagai, H. Maeda and N. Ishida: Biological activity of neocarzinostain and its derivatives. Antimicrobial Agents Chemotherapy, 546-550 (1966) (Am. Soc. Microbiology)
3. H. Maeda and N. Ishida: Specificity of biding of hexopyranosyl polysaccharides with fluorescent frightener. J. Biochem., 62, 276-278 (1967) 4. H. Maeda and N. Ishida: Conformational study of antitumor proteins. Neocarzinostain and a deaminated derivative. Biochim. Biophs. Acta, 147, 597-599 (1967) 5. R.E. Feeney, D.T. Osuga and H. Maeda: Heterogeneity of avian ovomucoids. Arch. Biochem. Biophys., 119, 124-132 (1967)
6. H. Maeda and H. Kawaguchi: A new method for the determination of N-terminus of peptido chain with fluorescein-isothiocyanate. Biochem. Biophys. Res. Comm., 31, 188-192 (1968) 7. H. Maeda, T. Koyanagi and N. Ishida: C-terminal amino acid of Neocarzinostain. Biochim. Biophys. Acta, 160, 249-251 (1968) 8. Y. Ono, Y. Ito, H. Maeda and N. Ishida: Mode of action of neo-carzino-stain-mediated DNA degradation in Sarcina Lutea. Biochim. Biophys. Acta, 155, 616-618 (1968) 9. S. Kitame, H. Maeda, K. Kumagai and N. Ishida: Tryptic digestion of an antitumor protein: neocarzinostain. J. Antibiotics, 21, 460-462 (1968)
10. M. takahashi, K. Toriyama, H. Maeda, M. Kikuchi, K. Kumagai and N. Ishida: Clinical trials of a new antitumor polypeptide: Neo-carzinostain. Tohoku J. Exp. Med., 98, 273-280 (1969) 11. H. Maeda, H. Kawaguchi, K. Tsujimura and N. Ishida: Reaction of fluorescein-isothiocyanate with proteins and amino acids I. Co-valent and non-covalent binding of fluorescein-isothocyanateand fluorescein to proteins. J. Biochem., 65, 777-783 (1969) 12. N. Ishida, F. Suzuki, H. Maeda K. Ozu and K. Kumagai: Isolation and characterization of lymphomycin. J. Anibiocics, 22, 118-227 (1969) 13. H. Kawaguchi, K. Tsujimura, H. Maeda and N. ishida: Reaction of fluorescein-isothiocyanate with protein and amino acids. Part U. J. Biochem., 65, 783-791 (1969)
14. H. Maeda and J. Meienhofer: On the typtophan content of neocarzinostain. Int. J. Protein Res., 2, 135-136 (1970) 15. H. Maeda, C.B. glaser and J. Meienhofer: Facile assignment of desulfide bonds in protein through detection of cystine containing peptides in peptide maps. Bioche. Biophys. Res. Comm., 39, 1211-1218 (1970) 16. H. Maeda and J. Meienhofer: Amino and carboxyterminal sequences of neocarzinostain, an antitumor polyperptide antibiotic. FEBS Letters, 9, 301-303 (1970) 17. C.B. Glaser, H. Maeda and J. Meienhofer: Chromatographic detention of thiols, disulfides and thioesters with 5, 5f-dithio (2-nitrobenzonic acid). J. chromato., 50, 151-154 (1970) 18. H. Maeda, C.B. Glaser, J. Meienhofer: Detention of disulfide bonds on peptide maps. Fed. Proc., 29, 278 (1970)
19. J. Meienhofer, J. Czombos and H. Maeda: Reduction of disulfide bonds in liquid ammonia. J. Am. Chem. Soc., 93, 3080-3081 (1971)
20. C.B. Glaser, H. Maeda and J. Meienhofer: Partial sequence of Tyrosine region of Neocarzinostain. Experientia, 28, 772-773 (1972) 21. J. Meienhofer, H. Maeda C.B. Glaser and H. Czombos: Structure of antitumor protein antibiotic, neocarzinostain. Science, 178, 875-876 (1972) 22. H. Maeda, Chales B. Glaser and Jozsef Czombos: Structual studies on neocarzinostain, an antitumor polypeptide antibiotic. Progress in Peptide research, 2, 295-306
23. H. Maeda, H. Shiroishi, s. Onodera and N. Ishida: conformation of antitumor antibiotic protein, neocarzinostain, studied by plane polarized infrared spectroscopy, circular dichroism and optical rotatory dispersion. Int. J. Peptide Protein Res., 5, 19-26 (1973)
24. C.B.Glaser, H. Maeda and J. Meienhofer: Facile assignment of disulfide bonds in ovine lactogenic hormone and human growth hormone. Int. J. Peptide and Protein Res., 6, 223-229 (1974) 25. T.S.A. Samy, M. Atreyi, H. Maeda and J. Meienhofer: Selective tryptophan oxidation in the antitumor protein neocarzinostatin and effects on conformation and biological activity. Biochemistry, 13, 1007-1014 (1974) 26. H. Maeda, C.B. Glaser, J. Czombos and J. Meienhofer: Structure of the antitumor protein neocarzinostatin. Purification, amino acid composition, disulfide reduction, and isolation and composition of tryptic peptides. Arch. Biochem. Biophys., 164, 369-378 (1974) 27. H. Maeda, C.B. Glaser, K. Kuromizu and J. Meienhofer: Structure of the antitumor protein neocarzinostatin. Amino acid sequence. Arch. Biochem. Biophys., 164, 379-385 (1974) 28. H. Maeda: Preparation of succinyl neocarzinostatin. Antimicrobial Agents Chemotherapy, 5, 354-355 (1974) 29. H. Maeda: Chemical and biological characterization of succinyl neocarzinostatin. J. Antibiotics, 27, 303-311 (1974)
30. H. Maeda, S. Aikawa and A. Yamashita: Subcellular fate of protein antibiotic neocarzinostatin in culture of a lymphoid cell line from Burkitt's lymphoma. Cancer Res., 35, 554-559 (1975) 31. H. Maeda and J. Takeshita: Degradation of neocarzinostatin by blood sera in vitro and its inhibition by diisopropyl fluorophosphate and N-ethylmaleimide. Gann, 66, 523-527 (1975)
32. H. Maeda and J. Takeshita: Inhibitors of proteolytic enzymes prevent the inactivation by blood of the protein antibiotic neocarzinostatin and its succinyl derivative. J. Antibiotics, 29, 111-112 (1976) 33. H. Maeda, N. Yamamoto and A. Yamashita: Fate and distribution of [14C] succinyl neocarzinostatin in rats. Europ. J. Cancer, 12, 865-870 (1976) 34. H. Maeda, N. Yamamoto, T. Nagoya, K. Kurosawa and F. Kobayashi: Release of formaldehyde from dimethylol dimethylhydantoin, a possible antiseptic agent. Agri. Biol. Chem., 40, 1705-1709 (1976) 35. N. Yamamoto, H. Maeda and H. Kanagawa: Ascitic fluid of malignant patients: Biochemical analysis and nature of growth promoting activity of cells in cuture. Jap. J. Clin. Oncol., 6, 39-48 (1976)
36. H. Maeda and K. Kuromizu: Spontaneous deamidation of a protein antibiotic, neocarzinostatin, at weakly acidic pH: Conversion to a homologous inactive preneocarzinostatin due to change of asparagine 83 to aspartic acid 83 accompanied by conformational and biological alterations. J. Biochem., 81, 25-35 (1977) 37. H. Maeda, S.Sakamoto and J. Ogata: Mechanism of accumulation of the antitumor protein antibiotic neocarzinostatin in bladder tissue: Intravenous administration, urinary excretion, and absorption into bladder tissue. Antimicrobial Agents Chemotherapy, 11, 941-945 (1977)
38. S. Sakamoto, J. Ogata, K. Ikegami and H. Maeda: Effects of systemic administration of neocarzinostatin, a new protein antibiotic, on human bladder cancer. Cancer Treat Rep., 62, 453-454 (1978) 39. H. Maeda, H. Ichimura, H. Satoh and K. Ohtsuki: Evaluation of succinyl neocarzinostatin in vivo. J. Antibiotics, 31, 468-472 (1978) 40. H. Maeda: Assay of an antitumor protein, neocarzinostatin, and its antibody by fluorescence polarization. Clin. Chem., 24, 2139-2144 (1978) 41. T. Fujii, H. Maeda, F. Suzuki and N. Ishida: Isolation and characterization of a new antitumor polysaccharide, KS-2, extracted from culture mycelia of Lentinus edodes. J. Antibiotics, 31, 1079-1090 (1978) 42. S. Sakamoto, H. Maeda, T. Matsumoto and J. Ogata: Experimental and clinical studies on the formation of antibodies to neocarzinostatin, a new protein antibiotic. Cancer Treat. Rep., 62, 2063-2070 (1978)
43. H. Maeda: Assay of proteolytic enzymes by the fluorescence polarization technique. Anal. Biochem., 92, 222-227 (1979) 44. H. Maeda and M. Matsumoto: Cytotoxic effect of neocarzinostatin on human lymphoid cells. Tohoku J. Exp. Med., 128, 313-323 (1979) 45. A. Yamashita, Y. Kitawaki, M. Miyamoto and H. Maeda: Suppression of graft-versus-host reaction by preincubation of the graft with an antitumor protein, neocarzinostatin. Immunopharmacology, 1, 255-265 (1979) 46. H. Maeda, J. Takeshita and R. Kanamaru: A lipophilic derivative of neocarzinostatin: A polymer conjugation of an antitumor protein antibiotic. Int'l. J. Peptide Protein Res., 14, 81-87 (1979) 47. S. Sakamoto, H. Maeda and J. Ogata: An uptake of fluorescein isothiocyanate labeled neocarzinostatin into the cancer and normal cells. Experientia, 35, 1223-1234 (1979) 48. H. Maeda, J. Takeshita, R. Kanamaru, H. Sato, J. Khatoh and H. Sato: Antimetastatic and antitumor activity of a derivative of neocarzinostatin: An organic solvent- and water-soluble polymer- conjugated protein. Gann, 70, 601-606 (1979) 49. F. Suzuki, C. Suzuki, E. Shimomura, H. Maeda, T. Fujii, N. Ishida: Antiviral and interferon-inducing activities of a new peptidomannnan, KS-2, extracted from culture mycelia of Lentinus edodes. J. Antibiotics, 32, 1336-1345 (1979) [Monograph] 50. H. Maeda, M. Nakayama, D. Iwaoka and T. Sato: Assay of Angiotensin I by fluorescence polarization method. In KININS-II:Biochemistry, Pathophysiology, and Clinical Aspects. (eds: S. Fujii, H. Moriya, T. Suzuki) Plenum Publishing Corporation. New York, P. 203-211 (1979)
51. K. Kinoshita, H. Maeda and Y. Hinuma: Fluorescence polarization assay of plasmin, plasminogen, and plasminogen activator. Anal. Biochem., 104, 15-22 (1980) 52. S. Sakamoto, J. Ogata, K. Ikegami and H. Maeda: Chemotherapy for bladder cancer with neocarzinostatin: Evaluation of systemic administration. Eur. J. Cancer., 16, 103-113 (1980) 53. H. Maeda, J. Takeshita and A. Yamashita: Lymphotropic accumulation of an antitumor antibiotic protein, neocarzinostatin. Eur. J. Cancer, 16, 723-731 (1980) 54. H. Maeda, K. Nishi and I. Mori: Facilitating effects alpha-1 acid glycoprotein on the passage of erythrocytes through the membrane-filter. Life Science, 27, 157-161 (1980) 55. H. Maeda, O. Murakami, M. Kann and I. Yamane: The growth-stimulating effect of a1-acid glycoprotein in cells in culture. Proc. Soc. Exp. Biol. Med., 163, 223-227 (1980) 56. Y. Kitamoto and H. Maeda: Reevaluation of the reaction of formaldehyde at low concentration with amino acids. J. Biochem., 87, 1519-1530 (1980) 57. J. Takeshita, H. Maeda and K. Koike: Subcellular action of neocarzinostatin: Intracellular incorporation, DNA breakdown and cytotoxicity. J. Biochem., 88, 1071-1080 (1980) 58. H. Maeda: A new lysozyme assay based on fluorescence polarization or fluorescene intensity utilizing a fluorescent peptidoglycan substrate. J. Biochem., 88, 1185-1191 (1980) 59. J.W. Brodrick, C.B. Glaser, C. Largman, M.C. Geokas, M. Graceffo, M. Fassett and H. Maeda: Interaciton of chymotrypsinogens with a1-protease inhibitor. Biochemistry, 19, 4865-4870 (1980)
60. S. Sakamoto, H. Maeda, K. Yamasaki, S. Aikawa and Y. Hinuma: Evaluation of cellular fluidity of peripheral blood lymphocytes from patients with urogenital cancers by a fluorescence polarization technique: PHA response and prognosis. Eur. J. Cancer Clin. Oncol., 17, 1105-1115 (1981) 61. H. Tsuda, H. Maeda and S. Kishimoto: Fluorescence polarization with FDA in leukaemic cells: A clear difference between myelogenous and lymphocytic origins. Br. J. Cancer, 43, 793-803 (1981) 62. H. Maeda: Neocarzinostatin in cancer chemotherapy (review). Anticancer Res., 1, 175-186 (1981) 63. H. Maeda, Y. Sano, J. Takeshita, Z. Iwai, H. Kosaka, T. Marubayashi and Y. Matsukado: A pharmacokinetic simulation model for chemotherapy of brain tumor with an antitumor protein antibiotic, neocarzinostatin: Theoretical considerations behind a two-compartment model for continuous infusion via an internal carotid artery. Cancer Chemother. Pharmacol., 5, 243-249 (1981) [Monograph] 64. H. Maeda, A. Yamashita, H. Ohtsuka: Oral administration, absorption and excretion of antitumor peptidomannan, KS-2, in rats. In Immunomodulation by Microbial Products and Related Synthetic Compounds (eds: Y. Yamamura, S. Kotani, I. Azuma, A. Koda and T. Shiba); Excerpta Medica Amsterdam-Oxford- Princeton, 431-434 (1981)
65. J. Takeshita, H. Maeda and R. Kanamaru: In vitro mode of action, pharmacokinetics, and organ specificity of poly (maleic acid-styrene)-conjugated neocarzinostatin, SMANCS. Gann, 73, 278-284 (1982) 66. M. Yamaki, H. Ohori, S. Onodera, N. Ishida and H. Maeda: Circular dichroism and biochemical properties of the hepatitis B virus core antigen. Biochem. Biophys. Acta., 706, 165-173 (1982) 67. K. Yonemura and H. Maeda: A New assay method for DNase by fluorescence polarization and fluorescence intensity using DNA-ethidium bromide complex as a sensitive substrate. J. Biochem., 92, 1297-1303 (1982) 68. H. Tsuda and H. Maeda: Investigation of factors involved in the uptake velocity of fluorescein diacetate and intracellular fluorescence polarization value. I. Physiological aspects in lymphoblastoid cells. Cell Struct. and Funct., 7, 165-175 (1982) 69. H. Maeda, H. Tsuda, J. Takeshita: Investigation of factors involved in the uptake velocity of fluorescein diacetate and intracellular fluorescence polarization value. II. Cytotoxicity produced by anticancer agents. Cell Struct. and Funct., 7, 177-182 (1982)
70. A. Yamashita, H. Ohtsuka and H. Maeda: Intestinal absorption and urinary excretion of antitumor peptidomannan KS-2 after oral administration in rats. Immunopharmacology, 5, 209-220 (1983) 71. K. Yonemura, K. Matsumoto and H. Maeda: Isolation and characterization of nucleases from a clinical isolate of Serratia marcescens kums 3958. J. Biochem., 93, 1287-1295 (1983) 72. T. Konno, H. Maeda, K. Iwai, S. Tashiro, S. Maki, T. Morinaga, M. Mochinaga, T. Hiraoka and I. Yokoyama: Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: A preliminary report. Eur. J. Cancer Clin. Oncol., 19, 1053-1065 (1983)
73. K. Matsumoto, H. Maeda, K. Takata, R. Kamata and R. Okamura: Purification and characterization of four proteases from a clinical isolate of Serratia marcescens kums 3958. J. Bacteriol., 157, 225-232 (1984) 74. K. Iwai, H. Maeda and T. Konno: Use of oily contrast medium for selective drug targeting to tumor: Enhanced therapeutic effect and X-ray image. Cancer Res., 44, 2115-2121 (1984) 75. T. Konno, H. Maeda, K. Iwai, S. Maki, S. Tashiro, M. Uchida and Y. Miyauchi: Selective targeting of anticancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium. Cancer, 54, 2367-2374 (1984) 76. H. Maeda, T. Matsumoto, T. Konno. K. Iwai and M. Ueda: Tailor-making of protein drugs by polymer conjugation for tumor targeting: A brief review on smancs. J. Prot. Chem., 3, 181-193 (1984) 77. B.W. Gibson, W.C. Herlihy, T.S.A. Samy, K.-S. Hahm, H. Maeda, J. Meienhofer and K. Biemann: A revised primary structure for neocarzinostatin based on fast atom bombardment and gas chromotagraphic-mass spectormetry. J. Biol., Chem., 259, 10801-10806 (1984) 78. K. Matsumoto, T. Yamamoto, R. Kamata and H. Maeda: Pathogenesis of serratial infection: Activation of the Hageman factor-prekallikrein cascade by serratial protease. J. Biochem., 96, 739-749 (1984) 79. K. Matsumoto, H. Maeda and R. Okamura: Role of the zinc atom in the activity and conformational stabilirty of serratial 56K protease. A fluorometric study. J. Biochem., 96, 1165-1173 (1984) 80. H. Maeda, T. Morinaga, I. Mori and K. Nishi: Further characterization of effects of alpha-1-acid glycoprotein on the passage of human erythrocytes through micropores. Cell Struct. and Funct., 9, 279-290 (1984)
81. Y. Yumoto, K. Jinno, K. Tokuyama, Y. Araki, T. Ishimitsu, H. Maeda, T. Konno, S. Iwamoto. K. Ohnishi and K. Okuda: Hepatocellular carcinoma detected by lodizied oil. Radiology, 154, 19-24 (1985) 82. H. Maeda, M. Ueda, T. Morinaga and T. Matsumoto: Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: Pronounced improvements in pharmacological properties. J. Med. Chem., 28, 455-461 (1985) 83. S. Maki, T. Konno and H. Maeda: Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium. Cancer, 56, 751-757 (1985) 84. T. Shimada, H. Kato, H. Maeda and S. Iwanaga: Interaction of factor XII, high-molecular-weight (HMW) kininogen and prekallikrein with sulfatide: Analysis by fluorescence polarization. J. Biochem., 97, 1637-1644 (1985) 85. R. Kamata, T. Yamamoto, K. Matsumoto and H. Maeda: A serratial protease causes vascular permeability reaction by activation of the Hageman factor-dependent pathway in guinea pigs. Infect. Immun., 48, 747-753 (1985)
86. R. Kamata, K. Matsumoto, R. Okamura, T. Yamamotoand H. Maeda: The serratial 56K protease as a major pathogenic factor in serratial keratitis: Clinical and experimental study. Ophthalmol., 92, 1452-1459 (1986) 87. T. Oda, T. Morinagaand H. Maeda: Stimulation of macrophage by polyanions and its conjugated proteins and effect on cell membrane. Proc. Soc. Exp. Biol. Med., 181, 9-17 (1986) 88. F. Suzuki, H. Maeda, R.B. Pollard: Suppression of interferon gamma production in mice treated with carrageenan. Eur. J. Immunol., 16, 375-380 (1986) 89. T. Oda and H. Maeda: A new simple fluorometric assay for phagocytosis. J. Immunol. Methods, 88, 175-183 (1986) 90. K. Kuromizu, S. Tsunasawa, H. Maeda, O. Abe and F. Sakiyama: Reexamination of the primary structure of an antitumor protein, neocarzinostatin. Arch. Biochem. Biophys., 246, 199-205 (1986) 91. A. Molla, K. Matsumoto, I. Oyamada, T. Katsuki and H. Maeda: Degradation of protease inhibitors, immunoglobulins, and other serum proteins by Serratia protease and its toxicity to fibroblasts in culture. Infect. Immun., 53, 522-529 (1986) 92. Y. Matsumura and H. Maeda: A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS. Cancer Res., 46, 6387-6392 (1986) [Monograph] 93. H. Maeda, Y. Matsumura, T. Oda and K. Sasamoto: Cancer selective macromolecular therapeutics: Tailoring of an antitumor protein drug. In Protein Tailoring for Food and Medical Uses (eds: R.E. Feeney and J.R. Whitaker), Marcel Dekker, Inc., New York-Basel, p. 353-382 (1986) 94. K. Matsumoto, T. Yamamoto, R. Kamata and H. Maeda: Enhancement of vascular permeability upon serratial infection: Activation of Hageman factor-kallikrein-kinin cascade. In KININS IV, Part.B (eds: L.M. Greenbaum and H.S. Margolius) Plenum Publishing Corporation, New York, p.71-78 (1986)
95. H. Maeda, Y. Matsumura and A. Molla: Antitumor activity of some bacterial proteases: Eradication of solid tumors in mice by intratumor injection. Cancer Res., 47, 563-566 (1987) 96. K. Yamasaki, T. Konno, Y. Miyauch and H. Maeda: Reduction of hepatic metastases in rabbits by administration of an oily anticancer agent into the portal vein. Cancer Res., 47, 852-855 (1987) 97. T. Oda and H. Maeda: Binding to and internalization by cultured cells of neocarzinostatin and enhancement of its actions by conjugation with lipophilic styrene-maleic acid copolymer. Cancer Res., 47, 3206-3211 (1987) 98. A. Molla, T. Oda and H. Maeda: Different binding kinetics of Serratia 56K protease with plasma a2-macroglobulin and chicken egg white ovomacroglobulin. J. Biochem., 101, 199-205 (1987) 99. N. Ohtsuka, T. Konno, Y. Miyauchi and H. Maeda: Anticancer effects of arterial administration of the anticancer agent SMANCS with Lipiodol on metastatic lymph nodes. Cancer, 59, 1560-1565 (1987) 100.K. Iwai, H. Maeda, T. Konno, Y. Matsumura, R. Yamashita, K. Yamasaki. S. Hirayama and Y. Miyauchi: Tumor targeting by arterial administration of lipids: Rabbit model with VX2 carcinoma in the liver. Anticancer Res., 7, 321-328 (1987) 101.T. Oda, F. Sato and H. Maeda: Facilitated internalization of neocarzinostatin and its lipophilic polymer conjugate, SMANCS, into cytosol in acidic pH. J. Nat. Cancer Inst., 79, 1205-1211 (1987) 102.H. Maeda, A. Molla, T. Oda and T. Katsuki: Internalization of serratial protease into cells as an enzyme-inhibitor complex with alpha2-macroglobulin and regeneration of protease activity and cytotoxicity. J. Biol. Chem., 262, 10946-10950 (1987) 103.A. Molla, Y. Matsumura, T. Yamamoto. R. Okamura and H. Maeda: Pathogenic capacity of proteases from Serratia marcescene and Psudomonas aeruginosa and their suppression by chicken egg white ovomacroglobulin. Infec. Immun., 55, 2509-2517 (1987) 104.T. Okamoto, K. Ueda, H. Maeda and T. Kambara: Determination of lysozyme activity by fluorescence polarization in rheumatoid synovial fluids and release of lysozyme from polymorphonuclear leukocytes by chemotactic factors. J. Immunol. Methods, 103, 221-227 (1987) [Monograph] 105.N. Nishino, W. Shimizu, M. Hirotsuka, T. Fujimoto and H. Maeda: New synthetic substrates and inhibitors of serratial 56K protease. In Peptide Chemistry 1986 (ed. T. Miyazaki) Protein Research Foundation, Osaka, 233-236 (1987) 106.T. Konno and H. Maeda: Targeting Chemotherapy of Hepatocellular Carcinoma. Springer-Verlag, In Neoplasms of the liver (eds: K. Okuda and K. G. Ishak) Tokyo-Berlin-Heidelberg-New York., 343-352 (1987)
107.H. Maeda, T. Oda, Y. Matsumura and M. Kimura: Improvement of pharmacological properties of protein-drugs by tailoring with synthtric polymers. J. Bioactive Compatible Polymers, 3, 27-43 (1988) 108.A. Molla, T. Yamamoto and H. Maeda: Characterization of 73kDa thiol protease from Serratia marcescens and its effect on plasma proteins. J. Biochem., 104, 616-621 (1988) 109.A. Molla, T. Kagimoto and H. Maeda: Cleavage of Immunoglobulin G(IgG) and IgA around the hinge region by proteases from Serratia marcescens. Infect. Immun., 56, 916-920 (1988) 110.A. Molla, S. Tanase, Y. Hong and H. Maeda: Interdomain cleavage of plasma fibronectin by zinc-metalloproteinase from Serratia marcescens. Biochem. Biophys. Acta, 955, 77-85 (1988) 111.F. Suzuki, T. Munakata and H. Maeda: Interferon induction by SMANCS: A polymer-conjugated derivative of neocarzinostatin. Anticancer Res., 8, 97-104 (1988) 112.M. Kimura, Y. Matsumura, Y. Miyauchi and H. Maeda: A new tactic for the treatment of jaundice: An injectable polymer-conjugated bilirubin oxidase. Proc. Soc. Exp. Biol. Med., 188, 364-369 (1988) 113.H. Maeda, Y. Matsumura and H. Kato: Purification and identification of [hydroxyprolyl3] bradykinin in ascitic fluid from a patient with gastric cancer. J. Biol Chem., 263, 16051-16054 (1988) 114.H. Kato, Y Matsumura and H. Maeda: Isolation and identification of hydroxyproline analogues of bradykinin in human urine. FEBS Letters, 232, 252-254 (1988) 115.Y. Matsumura, M. Kimura, T. Yamamoto and H. Maeda: Involvement of the kinin-generating cascade and enhanced vascular permeability in tumor tissue. Jpn. J. cancer Res., 79, 1327-1334 (1988) 116.H. Maeda: YM-881, SMANCS, styrene-co-maleic acid conjugated neocarzinostatin. Drug of the Future, 13, 841-842 (1988) 117.T. Ogino, M. Inoue, Y. Ando, M. Awai, H. Maeda and Y. Morino: Chemical modification of superoxide dismutase. Int. J. Peptid Protein Res., 32, 153-159 (1988) 118.A. Kobayashi, T. Oda and H. Maeda: Protein binding of macromolecular anticancer agent SMANCS: Characterization of poly(styrene-co-maleic acid) derivatives as an albumin binding ligand. J. Bioactive Compatible Polymers, 3, 319-333 (1988) [Monograph] 119.T. Oda, T. Akaike. T. Hirano and H. Maeda: Therapeutic effect of pyran-copolymer conjugated SOD on the mouse influenza virus infection. In Medical Biochemical and Chemical Aspects of Free Radicals (eds: O. Hayaishi, E. Niki, M. Kondo and T. Yoshikawa), Elsevier Science Publishers, Amsterdam, p. 747-750 (1988) 120.K. Kitagawa, M. Matsumoto, T. Oda, H. Maeda, N. Handa, R. Fukunaga, K. Kimura and T. Kamada: Protective effect of pyran-conjugated superoxide dismutase on experimental cerebral ischemia. In Medical Biochemical and Chemical Aspects of Free Radicals (eds. O. Hayaishi, E. Niki, M. Kondo and T. Yoshikawa), Elsevier Science Publishers, Amsterdam, p. 655-658 (1988)
121.H. Maeda, A. Molla, K. Sakamoto, A. Murakami and Y. Matsumura: Cytotoxicity of bacterial proteases in various tumor cells mediated through alpha2-macroglobulin receptor. Cancer Res., 49, 660-664 (1989) 122.A. Molla, T. Akaike and H. Maeda: Inactivation of various proteinase inhibitors and the complement system in human plasma by the 56-kilodalton proteinase from Serratia marcescens. Infect. Immun., 57, 1868-1871 (1989) 123.A. Molla, T. Yamamoto, T. Akaike, S. Miyoshi and H. Maeda: Activation of Hageman factor and prekallikrein and generation of kinin by various microbial proteinases. J. Biol. Chem., 264, 10589-10594 (1989) 124.T. Akaike., A. Molla, M. Ando, S. Araki and H. Maeda: Molecular mechanism of complex infection by bacteria and virus analyzed by a model using serratial protease and influenza virus in mice. J. Virol., 63, 2252-2259 (1989) 125.T. Oda, T. Akaike, T. Hamamoto, F. Suzuki, T. Hirano and H. Maeda: Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science, 244, 974-976 (1989) 126.T. Oda, F. Sato, H. Yamamoto, M. Akagi and H. Maeda: Cytotoxicity of smancs in comparison with other anticancer agents against various cells in culture. Anticancer Res., 9, 261-266 (1989) 127.Y. Takakura, Y. Kaneko, T. Fujita, M. Hashida, H. Maeda and H. Sezaki: Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran I: Synthesis and characterization. J. Pharmaceut. Sci., 78, 117-121 (1989) 128.Y. Takakura, T. Fujita, M. Hashida, H. Maeda and H. Sezaki: Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran II: Biopharmaceutical and pharmacological properties. J. Pharmaceut. Sci., 78, 219-222 (1989) 129.S. Kurooka, K. Kaibe, H. Ueyama, K. Kido, Y. Matsumura, H. Maeda and H. Kato: The specific determination of hydroxyprolyl-3-bradykinin using a competitive binding enzyme immunoassay. J. Immunol. Methods, 118, 147-149 (1989) 130.T. Oda, H. Yamamoto, T. Miki and H. Maeda: Differential neutralizing effect of tiopronin on the toxicity of neocarzinostatin and SMANCS: A new rescue cancer chemotherapy. Jpn. J. Cancer Res., 80, 394-399 (1989) 131.R.R. Brutkiewicz, F. Suzuki, R.B. Pollard and H. Maeda: Ge-132: An immunomodulating compound for use in anticancer therapy. Drug News & Perspectives, 2, 362 (1989) 132.H. Maeda and Y. Matsumura: Tumoritropic and lymphotropic principles of macromolecular drugs. Critical Reviews in Therap Drug Carrier Systems, 6, 193-210 (1989) 133.H. Maeda, A. Molla: Pathogenic potentials of bacterial proteases. Clin. Chim. Acta, 185, 357-368 (1989) 134.F. Suzuki, R.B. Pollard and H. Maeda: Stimulation of non-specific resistance to tumors in the mouse using a poly (maleic-acid-styrene)-conjugated neocarzinostatin. Cancer Immunol. Immunother., 30, 97-104 (1989) [Monograph] 135.N. Nishino, W. Shimizu, T. Fujimoto and H. Maeda: Inhibition of serratia 56K protease by peptidyl mercaptoanilides. In Peptide Chemistry 1988 (ed. M. Ueki) Protein Research Foundation, Osaka, 21-24 (1989) 136.H. Maeda and Y. Matsumura: New tactics and basic mechanism of targeting chemotherapy in solid tumors. In Cancer Chemotherapy: Challenges for the Future, Vol. 4 (ed. K. Kuimura et al.) Excerpta Medica, Tokyo, p.42-50 (1989) 137.Y. Matsumura, M. Kimura, H. Kato, T. Yamamoto and H. Maeda: Quantification, isolation and structural determination of bradykinin and hydroxyprolyl-bradykinin in tumor ascites. In KININS V. part A (eds. K. Abe, H. Moriya and S. Fujii) Plenum Publishing, New York, P. 587-592 (1989)
138.Y. Matsumura, H. Maeda and H. Kato: Degradation pathway of kinins in tumor ascites and inhibition by kininase inhibitors: Analysis by HPLC. Agents Actions, 29, 172-180 (1990) 139.T. Akaike, M. Ando, T. Oda, T. Doi, S. Ijiri, S. Araki and H. Maeda: Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J. Clin. Invest., 85, 739-745 (1990) 140.T. Oda, Y. Kojima, T. Akaike, S. Ijiri, A. Molla and H. Maeda: Inactivation of chemotactic activity of C5a by the serratial 56-kilodalton protease. Infect. Immun., 58, 1269-1272 (1990) 141.K. Oka, Y. Miyamoto. Y. Matsumura, S. Tanaka, T. Oda, F. Suzuki and H. Maeda: Enhanced intestinal absorption of a hydrophobic polymer-conjugated protein drug, smancs, in an oily formulation. Pharmaceut. Res., 7, 852-855 (1990) 142.Y. Miyamoto, T. Oda and H. Maeda: Comparison of the cytotoxic effects of the high-and low-molecular-weight anticancer agents on multidrug-resistant Chinese hamster ovary cells in vitro. Cancer Res., 50, 1571-1575 (1990) 143.F. Suzuki, R.B. Pollard, S. Uchimura, T. Munakata and H. Maeda: Role of natural killer cells and macrophages in the nonspecific resistance to tumors in mice stimulated with SMANCS, a polymer-conjugated derivative of neocarzinostatin. Cancer Res., 50, 3897-3904 (1990) 144.M. Kimura, Y. Matsumura, T. Konno, Y. Miyauchi and H. Maeda: Enzymatic removal of bilirubin toxicity by bilirubin oxidase in vitro and excretion of degradation products in vivo. Proc. Soc. Exp. Biol. Med., 195, 64-69 (1990) 145.H. Kaminishi, M. Tanaka, T. Cho, H. Maeda and Y. Hagihara: Activation of the plasma kallikrein-kinin system by Candida albicans proteinase. Infect. Immun., 58, 2139-2143 (1990) 146.K. Kitagawa, M. Matsumoto, T. Oda, M. Ninobe, R. Hata, N. Handa, R. Fukunaga, Y. Isaka, K. Kimura, H. Maeda, K. Mikoshiba and T. Kamada: Free radical generation during brief period of cerebral ischemia may trigger delayed neuronal death. Neuroscie, 35, 551-558 (1990) 147.H. Yamamoto, T. Miki, T. Oda, T. Hirano, Y. Sera, M. Akagi and H. Maeda: Reduced bone marrow toxicity of neocarzinostatin by conjugation with divinyl ether-maleic acid copolymer. Eur. J. Cancer, 26, 253-260 (1990) 148.H. Kobayashi, H. Aso, N. Ishida, H. Maeda, R.B. Pollard and F. Suzuki: Depletion of macrophages expressing I-J antigen results in efficient generation of alloreactive cytotoxic T. Lymphocytes. Cellular Immunol., 128, 589-602 (1990)
149.K. Maruo, T. Akaike Y. Matsumura, S. Kohmoto, Y. Inada, T. Ono, T. Arao and H. Maeda: Triggering of the vascular permeability reaction by activation of the Hageman factor-prekallikrein system by house dust mite proteinase. Biochim. Biophys. Acta, 1074, 62-68 (1991) 150.H. Maeda: SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy. Adv. Drug Delivery Rev., 6, 181-202 (1991) 151.Y. Miyamoto and H. Maeda: Enhancement by verapamil of neocarzinostatin action on multidrug-resistant Chinese hamster ovary cells: Possible release of nonprotein chromophore in cells. Jpn. J. Cancer Res., 82, 351-356 (1991) 152.Y. Matsumura, K. Maruo, M. Kimura, T. Yamamoto, T. Konno and H. Maeda: Kinin-generating cascade in advanced cancer patients and in vitro study. Jpn. J. Cancer Res., 82, 732-741 (1991) 153.S. Miyagawa, R. Kamata, K. Matsumoto, R. Okamura and H. Maeda: Inhibitory effects of ovomacroglobulin on bacterial keratitis in rabbits. Graefe's Arch. Ophthalmol., 229, 281-286 (1991) 154.M. Kobayashi, H. Maeda, K. Imai, T. Konno, S. Sugihara and H. Yamanaka: Tumor-targeted chemotherapy with lipid contrast medium and macromolecular anticancer drug (SMANCS) for renal cell carcinoma. Urology, 37, 288-294 (1991) 155.Y. Yumoto, K. Jinno, K. Tokuyama, T. Wada, H. Kobayashi, T. Okamoto, H. Toki, S. Inatsuki, K. Hara, S. Moriwaki, T. Tuji and H. Maeda: Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia for treatment of hepatocellular carcinoma. Int. J. Hyperthermia, 7, 7-17 (1991) 156.S. Miyagawa, N. Nisniho, R. Okamura and H. Maeda: Effects of protease inhibitors on growth of Serratia marcescens and Pseudomonas aeruginosa: Chicken egg white ovomacroglobulin is a potent growth suppressor. Microbial Pathogenesis, 11, 137- 141 (1991) 157.K. Kuromizu, O. Abe and H. Maeda: Location of the disulfide bonds in the antitumor protein, neocarzinostatin. Arch. Biochem. Biophys., 286, 569-573 (1991) 158.H. Maeda and T. Akaike: Oxygen free radicals as pathogenic molecules in viral diseases. Proc. Soc. Exp. Biol. Med., 198, 721-727 (1991) 159.S. Miyagawa. K. Matsumoto, R. Kamata, R. Okamura and H. Maeda: Spreading of Serratia marcescens in experimental keratitis and growth suppression by chicken egg white ovomacroblobulin. Jpn. J. Opthalmol., 35, 402-410 (1991) [Monograph] 160.H. Maeda, T. Akaike and K. Maruo: Pathogenic role of microbial proteases at celluar and moclecular levels. In Frontiers of Mucosal Immunology, Vol. 1. (eds. M. Tsuchiya, H. Nagura, T. Hibi and I. Moro) Elsevier Science publishers, Amsterdam, p. 553-558 (1991) 161.T. Akaike, K.Sato, M. Kohno and H. Maeda: PQQ as generator and a scavenger of oxygen radicals: Determination with ESR spectroscopy using a spin trap agent. In Enzymes Dependent on Pyridoxal Phosphate and Other Carbonyl Compounds as Confactors. (eds. T. Fukui, H. Kagamiyama, K. Soda and H. Wada) Pergamon Press, New York, p. 511-513 (1991) 162.H. Maeda: Protein drugs tailored with synthetic polymers: Enhanced plasma-half-life and efficient delivery to tumor and inflammatory sites. In High Performance Biomaterials: A Comprehensive Guide to Medical and Pharmaceutical Applications. (ed. M.Sztcner) Technomic Pub. Co. Inc., Lancaster-Basel, p. 765-778 (1991)
163.H. Maeda: The tumor blood vessel as an ideal target for macromolecular anticancer agents. J. Cont. Release, 19, 315-324 (1992) 164.T. Akaike, K. Sato, S. Ijiri, Y. Miyamoto, M. Kohno, M. Ando and H. Maeda: Bactericidal activity of alkyl peroxyl radicals generated by heme-iron-catalyzed decomposition of organic peroxides. Arch. Biochem. Biophys., 294, 55-63 (1992) 165.T. Oda, T. Akaike, K. Sato, A. Ishimatsu, S. Takeshita, T. Muramatsu and H. Maeda: Hydroxyl radical generation by red tide algae. Arch. Biochem, Biophys., 294, 38-43 (1992) 166.A. Kimoto, T. Konno, T. Kawaguchi, Y. Miyauchi and H. Maeda: Antitumor effects of SMANCS on rat mammary tumor induced by 7, 12-dimethylbenz[a]anthracene. Cancer Res., 52, 1013-1017 (1992) 167.A. Noguchi, T. Takahashi, T. Yamaguchi, K. Kitamura, A. Noguchi, H. Tsurumi, K. Takashina and H. Maeda: Enhanced tumor localization of monoclonal antibody by treatment with kininase II inhibitor and angiotensin II. Jpn. J. Cancer Res., 83, 240-243 (1992) 168.A. Murakami, K. Sakamoto, Y. Kojima, Y. Sasaki and H. Maeda: Antitumor effect of bacterial proteases on various human cancer xenografts in nude mice. Regional Cancer Treatment, 4, 200-206 (1992) 169.H. Kondo, S. Ijiri, K. Abe, H. Maeda and S. Arai: Inhibitory effect of oryzacystatins and a truncation mutant on the replication of poliovirus in infected Vero cells. FEBS Letters, 299, 48-50 (1992) 170.H. Maeda, T. Katsuki, T. Akaike and R. Yasutake: High correlation between lipid peroxide radical and tumor-promoter effect: Suppression of tumor promotion in the Epstein-Barr virus/B-lymphocyte system and scavenging of alkyl peroxide radicals by various vegetable extracts. Jpn. J. Cancer Res., 83, 923-928 (1992) 171.H. Maeda, L.W. Seymour and Y. Miyamoto: Conjugates of anticancer agetns and polymers: Advantages of macromolecular therapeutics in vivo. Bioconjugate Chemistry, 3, 351-362 (1992) 172.K. Sato, T. Akaike, M. Kohno, M. Ando and H. Maeda: Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme. J. Biol. Chem., 267, 25371-25377 (1992) 173.K. Sato, T. Akaike, Y. Kojima, M. Ando, M. Nagao and H. Maeda: Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH/cytochrome P-450 reductase in vitro. Jpn. J. Cancer Res., 83, 1204-1209 (1992) 174.H. Kobayashi, H. Aso, N. Ishida, H. Maeda, D.A. Schmitt, R. B. Pollard and F. Suzuki: Preventive effect of a synthetic immunomodulator, 2-carboxyethylgermanium sesquioxide, on the generation of suppressor macrophages in mice immunized with allogeneic lymphocytes. Immunopharmacol, Immunotoxicol., 14, 841-864 (1992) 175.D.A. Schmitt, K. Kisanuki, S. Kimura, K. Oka, R.B. Pollard, H. Maeda and F. Suzuki: Antitumor activity of orally administered SMANCS, a polymer-conjugated protein drug, in mice bearing various murine tumors. Anticancer Res., 12, 2219-2224 (1992) 176.A. Matsushima, Y. Kodera, S. Ozawa, M. Kobayashi, H. Maeda and Y. Inada: Inhibition of mite protease(Df-protease) with protease inhibitors. Biochem. Int'l., 28, 717-723 (1992) 177.T. Konno, R. Yamashita, T. Oda, H. Maeda, T. Taguchi and A. Nagamitsu: Targeting cancer chemotherapy used Lipiodol as a carrier of anticancer agents for hepatocellular carcinoma. Reg. Cancer Treat., 3-4, 110-116 (1992) [Monograph] 178.H. Maeda, M. Kimura, I. Sasaki, Y. Hirose and T. Konno: Toxicity of bilirubin and detoxification by PEG-bilirubin oxidase conjugate: A new tactic for treatment of jaundice. In Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications (ed. J. M. Harris) Plenum Press, New York, p. 153-169 (1992) 179.Y. Kojima, T. Akaike and H. Maeda: Free radical scavenging potential of the lung in influenza virus-infected mice. In Oxygen Radicals (eds. K. Yagi, M. Kondo, E. Niki and T. Yoshikawa) Elsevier Science Publishers, Amsterdam, p. 461-464 (1992) 180.H. Maeda, K. Maruo, T. Akaike, H. Kaminishi and Y. Hagiwara: Microbial proteinases as an universal trigger of kinin generation in microbial infections. In Agents and Actions Supplements Vol. 38/III Recent progress on kinins-pharmacological and clinical aspects of the kallikrein system part II. (eds. G. Bonner, H. Fritz, B. Schoelkens, G. Dietze, K. Luppertz) Birkhauser Verlag, Basel, p. 362-369 (1992)
181.T. Akaike, M. Yoshida, Y. Miyamoto, K. Sato, M. Kohno, K. Sasamoto, K. Miyazaki, S. Ueda and H. Maeda: Antagonistic action of imidazolineoxylN-oxides against endothelium-derived relaxing factor/₯NO through a radical reaction. Biochemistry, 32, 827-832 (1993) 182.K. Takahashi, T. Akaike, K. Sato, K. Mori and H. Maeda: Superoxide anion generation by pacific oyster (Crassostrea gigas) hemocytes: Identification by electron spin resonance spin trapping and chemiluminescence analysis. Comp. Biochem. Physiol., 105, 35-41 (1993) 183.Y. Kojima and H. Maeda: Evaluation of poly(vinyl alcohol) for protein tailoring: Improvements in pharmacokinetic properties of superoxide dismutase. J. Bioactive Compatible Polymers, 8, 115-131 (1993) 184.K. Kakimoto, Y. Kojima, K. Ishii, K. Onoue and H. Maeda: The suppressive effect of gelatin-conjugated superoxide dismutase on disease development and severity of collagen-induced arthritis in mice. Clin. Exp. Immunol., 94, 241-246 (1993) 185.F. Suzuki, D.A. Schmitt, R.B. Pollard and H. Maeda: Immunomodulating activities of orally administered SMANCS, a polymer conjugated derivative of the proteinaceous antibiotic neocarzinostatin, in an oily formulation. Int'l J. Immunopharmacol., 15, 175-183 (1993) 186.C.J. Li, Y. Miyamoto, Y. Kojima and H. Maeda: Augmentation of tumour delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure. Br. J. Cacner, 67, 975-980 (1993) 187.T. Doi, M. Ando, T. Akaike, M. Suga, K. Sato and H. Maeda: Resistance to nitric oxide Mycobacterium avium complex and its implication in pathogenesis. Infect. Immun., 61, 1980-1989 (1993) 188.K. Yoshida, T. Akaike, T. Doi, K. Sato, S. Ijiri, M. Suga, M. Ando and H. Maeda: Pronounced enhancement of NO-dependent antimicrobial action by an •NO-oxidizing agent, imidazolineoxyl N-oxide. Infect. Immun., 61, 3552-3555 (1993) 189.K. Maruo, T. Akaike, Y. Inada, I. Ohkubo, T. Ono and H. Maeda: Effect of microbial and mite proteases on low and high molecular weight kininogens. J. Biol. Chem., 268, 17711-17715 (1993) 190.M. Kimura, T. Konno, T. Oda, H. Maeda and Y. Miyauchi: Intracavitary treatment of malignant ascitic carcinomatosis with oily anticancer agents in rats. Anticancer Res., 13, 1287-1292 (1993) 191.Y. Kojima, A. Haruta, T. Imai, M. Otagiri and H. Maeda: Conjugation of Cu,Zn-superoxide dismutase with succinylated gelatin: pharmacological activity and cell-lubricating function. Bioconjugate Chem., 4, 490-498 (1993) 192.H. Kaminishi, T. Cho, T. Itoh, A. Iwata, K. Kawasaki, Y. Hagihara and H. Maeda: Vascular permeability enhancing activity of Porphyromonas gingivalisprotease in guinea pigs. FEMS Microbiol. Letters, 114, 109-114 (1993) 193.T. Tsuchida, T. Yasuyama, K. Higuchi, A. Watanabe, T. Urakami, T. Akaike, K. Sato and H. Maeda: The protective effect of pyrroloquinoline quinone and its derivatives against carbon tetrachloride-induced liver inhjury of rats. J. Gastroenterol. Hepatol., 8, 342-347 (1993) [Monograph] 194.H. Maeda, T. Akaike, Y. Sakata and K. Maruo: Role of bradykinin in microbial infection: Enhancement of septicemia by microbial proteinases and kinin. In Agents and Actions Supplements 42, Proteases, Proteases Inhibitor and Protease-Derived Peptides: Importance in Human Pathophysiology and Therapeutics. (eds. J.C.Chironis and J.E. Repine) Birkhauser Verlag AG, Switz., p.159-165 (1993) 195.F. Hudecz, Y. Kojima, Y. Miyamoto, J. Kajtar and H. Maeda: The effect of charge on the biodistribution of synthetic branched polypeptides in tumour bearing mice. In Proceedings of 6th International Symposium on Recent Advances in Drug Delivery Systems., Salt Lake City, Utah, USA, p. 143-144 (1993)
196.H. Maeda, Y. Noguchi, K. Sato and T. Akaike: Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor. Jpn. J. Cancer Res., 85, 331-334 (1994) 197.M. Kobayashi, J. Nishihara, Y. Fujii, H. Maeda, M. Hosokawa and N. Takeichi: Involvement of oxygen radicals in the differentiation of rat myelomonocytic leukemia cells in vitro and in vivo. Leukemia Res., 18, 199-203 (1994) 198.T. Hirano, T. Todoroki, S. Kato, H. Yamamoto, P. Caliceti, F. Veronese, H. maeda and S. Ohashi: Synthesis of the conjugate of superoxide dismutase with the copolymer of divinylether and maleic anhydride retaining enzymatic activity. J. Cont. Release, 28, 203-209 (1994) 199.M. Yoshida, T. Akaike, Y. Wada, K. Sato, K. Ikeda, S. Ueda and H. Maeda: Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity. Biochem. Biophys. Res. Commun., 202, 923-930 (1994) 200.S. Miyagawa, R. Kamata, K. Matsumoto, R. Okamura and H. Maeda: Therapeutic intervention with chicken egg white ovomacroglobulin and a new quinolone on experimental Pseudomonas keratitis. Graefe's Arch. Clin. Exp. Ophthalmol., 232, 488-493 (1994) 201.H. Kaminishi, H. Hamatake, T. Cho, T. Tamaki, N. Suenaga, T. Fujii, Y. Hagihara and H. Maeda: Activation of blood clotting factors by microbial proteinases. FEMS-Microbiol. Lett., 121, 327-332 (1994) 202.T. Akaike, H. Maeda, K. Maruo, Y. Sakata and K. Sato: Potentiation of infectivity and pathogenesis of influenza A virus by a house dust mite protease. J. Infect. Dis., 170, 1023-1026 (1994) 203.R. Tsunoda, K. Okumura, H. Ishizuka, T. Matsunaga, T. Tabuchi, H. Yasue, T. Akaike, K. Sato and H. Maeda: Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: In vivo and in vitro studies. Eur. J. Pharmacol., 262, 55-63 (1994) 204.H. Maeda, T. Akaike, M. Yoshida and M. Suga: Multiple functions of nitric oxide in pathophysiology and microbiology: Analysis by a new nitric oxide scavenger. J. Leukocyte Biology, 56, 588-592 (1994) 205.K. Sato, T. Akaike, M. Suga, M. Ando and H. Maeda: Generation of free radicals from neocarzinostatin mediated by NADPH/cytochrome P-450 reductase via activation of enediyne chromophore. Biochem. Biophys. Res. Commun., 205, 1716-1723 (1994) 206.C.J. Li, Y. Miyamoto, Y. Noguchi, M. Kimura and H. Maeda: Improved therapeutic effect of the macromolecular anticancer agent smancs combined with time lagged administration of antidote tiopronin. J. Exp. Clin. Cancer Res., 13, 397-404 (1994) [Monograph] 207.H. Maeda, K. Sato and T. Akaike: Inactivation and fragmentation ofΏ1-protease inhibitor by Cu,Zn-superoxide dismutase and hydrogen peroxide via liberation of hydroxyl radical. In Biological Functions of Proteinases and Inhibitors. (eds. N. Katsunuma, H. Fritz, K. Suzuki, and J. Travis) Karger and Japan Scientific Societies Press, Switzerland and Japan, p. 253-270 (1994) 208.H. Maeda and Y. Miyamoto: SMANCS approach: Oily formulations of protein drugs for arterial injection and for oral administration. In Drug Absorption Enhancement. (ed. A.G. de Boer) Harwood Academic Publishers GmbH, Netherlands, p. 221-247 (1994) 209.H. Maeda: Polymer conjugated macromolecular drugs for tumor-specific targeting. In Polymeric Site-Specific Pharmacotherapy. (ed. A.J. Domb) John Wiley & Sons Ltd., New York, p. 95-116 (1994) 210.T. Akaike and H. Maeda: Molecular pathogenesis of influenza virus pneumonia: Impacts of proteases, kinins and oxygen radicals derived from hosts. In Basic and Clinical Aspects of Pulmonary Fibrosis (ed. T. Takishima) CRC Press, Florida, p. 213-227 (1994) 211.H. Maeda: The clinical effects of neocarzinostatin and its polymer conjugate, SMANCS. In Enediyne Antibiotics as Antitumor Agents (eds. D.B. Borders and T.W. Doyle) Marcel Dekker, Inc, New York, p. 363-381 (1994)
212.H. Kaminishi, H. Miyaguchi, T. Tamaki, N. Suenaga, M. Hisamatsu, I. Mihashi, H. Matsumoto, H. Maeda and Y. Hagihara: Degradation of humoral host defense by Candida albicans proteinase. Infect. Immun., 63, 984-988 (1995) 213.L.W. Seymour, Y. Miyamoto, H. Maeda, M. Brereton, J. Strohalm, K. Ulbrich and R. Duncan: Influence of molecular weight on passive tumour-accumulation of a soluble macromolecular durg-carrier. Eur. J. Cancer, 31, 766-770 (1995) 214.H. Aoki, T. Akaike, K. Abe, M. Kuroda, S. Arai, R. Okamura, A. Negi and H. Maeda: Antiviral effect of oryzacystatin, a proteinase inhibitor in rice, against herpes simplex virus type 1 in vitro and in vivo. Antimicrob. Agents Chemother., 39, 846-849 (1995) 215.T. Akaike, S. Ijiri, K. Sato, T. Katsuki and H. Maeda: Determination of peroxyl radical-scavenging activity in food by using bactericidal action of alkyl peroxyl radical. J. Agric. Fd. Chem., 43, 1864-1870 (1995) 216.E. Masuda and H. Maeda: Antitumor resistance induced by zinostatin stymalamer (ZSS), a polymer-conjugated neocarzinostatin (NCS) derivative: I. Meth A tumor eradication and tumor-neutralizing activity in mice pretreated with ZSS or NCS. Cancer Immunol. Immunother., 40, 329-338 (1995) 217.J. Travis, J. Potempa and H. Maeda: Are bacterial proteinases pathogenic factors? Trends in Microbiol., 3, 405-407 (1995) [Monograph] 218.H. Maeda, K. Sato and T. Akaike: Superoxide radical generation from heterocyclic amines. In Proceedings of the 23rd International Symposium of the Princess Takamatsu Cancer Research Fund. Heterocyclic Amines in Cooked Foods: Possible Human Carcinogens (eds. R.H. Adamson, J.-A. Gustafsson, N. Ito, M. Nagao, T. Sugimura, K. Wakabayashi and Y. Yamazoe) Princeton Scientific Publishing Co., New Jersey, p. 103-112 (1995) 219.H. Maeda, T. Akaike, M. Yoshida, K. Sato and Y. Noguchi: A new nitric oxide scavenger, imidazolineoxyl N-oxide derivative and its effects. In The Role of Nitric Oxide in Physiology and Pathophysiology, (eds. H. Koprowski and H. Maeda), Springer-Verlag, Heidelberg, Berlin, p. 37-50 (1995) 220.H. Maeda and K. Morihara: In Methods in Enzymology, Chapter 27 "Serralysin and the Related Bacterial Proteases". Academic Press, N.Y., Vol. 248. (ed. A.J. Barret), p. 395-413 (1995)
221.R. Duncan, T.A. Connors and H. Maeda: [Editorial] Drug targeting in cancer therapy: The magic bullet, what next? J. Drug Targeting, 3, 317-319 (1996) 222.T. Akaike, Y. Noguchi, S. Ijiri, K. Setoguchi, M. Suga, Y.M. Zheng, B. Dietzschold and H. Maeda: Pathogenesis of influenza virus-induced pneumonia: Involvement of both nitric oxide and oxygen radicals. Proc. Natl. Acad. Sci. U.S.A., 93, 2448-2453 (1996) 223.Y.-H. Shin, Y. Kojima, M. Otagiri and H. Maeda: Conjugation of succinylated gelatin to soybean trypsin inhibitor. J. Bioact. Compat. Polymers, 11, 3-16 (1996) 224.K. Doi, T. Akaike, H. Horie, Y. Noguchi, S. Fujii, T. Beppu, M. Ogawa and H. Maeda: Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth. Cancer, 77, 1598-1604 (1996) 225.E. Masuda and H. Maeda: Changes in cellular components of spleen and lymph node cells and the effector cells responsible for Meth A tumor eradication induced by zinostatin stimalamer. Cancer Res., 56, 1868-1873 (1996) 226.Y. Miyamoto, T. Akaike, M. Yoshida, S. Goto, H. Horie and H. Maeda: Potentiation of nitric oxide-mediated vasorelaxation by xanthine oxidase inhibitors. Proc. Soc. Exp. Biol. Med., 211, 366-373 (1996) 227.H. Maeda, T. Akaike, J. Wu, Y. Noguchi and Y. Sakata: Bradykinin and nitric oxide in infectious disease and cancer. Immunopharmacology, 33, 222-230 (1996) 228.Y.-H. Shin, T. Akaike, M.M.H. Khan, Y. Sakata and H. Maeda: Further evidence of bradykinin involvement in septic shock: Reduction of kinin production in vivo and improved survival in rats by use of polymer tailored SBTI with longer t1/2. Immunopharmacology, 33, 369-373 (1996) 229.Y. Sakata, T. Akaike, M.M.H. Khan, Y. Ichinose, H. Hirayama, M. Suga, M. Ando and H. Maeda: Activation of bradykinin generating cascade by Vibrio cholerae protease. Immunopharmacology, 33, 377-379 (1996) 230.Y. Sakata, T. Akaike, M. Suga, S. Ijiri, M. Ando and H. Maeda: Bradykinin generation triggered by Pseudomonas proteases facilitates invasion of the systemic circulation by Pseudomonas aeruginosa. Microbiol. Immunol., 40, 415-423 (1996) 231.H. Maeda and T. Yamamoto: Pathogenic mechanisms induced by microbial proteases in microbial infections. Biological Chemistry, Hoppe-Seyler, 377, 217-226 (1996) 232.Y. Kojima, T. Akaike, K. Sato, H. Maeda and T. Hirano: Polymer conjugation to Cu,Zn-SOD and suppression of hydroxyl radical generation on exposure to H2O2: Improved stability of SOD in vitro and in vivo. J. Bioact. Compat. Polymers, 11, 169-190 (1996) 233.H. Maeda: Role of microbial proteases in pathogenesis. Microbiol. Immunol., 40, 685-699 (1996) 234.J. Noda, M. Otagiri, T. Akaike and H. Maeda: Pharmacological advantages of conjugation of Cu,Zn-superoxide dismutase with succinylated keratin fragment: Improvement of biological properties and resistance to oxidative damage. J. Pharmacol. Exp. Therapeut., 279, 162-171 (1996) 235.K. Setoguchi, M. Takeya, T. Akaike, M. Suga, R. Hattori, H. Maeda, M. Ando and K. Takahashi: Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats. Am. J. Pathol., 149, 2005-2022 (1996) [Monograph] 236.T. Akaike and H. Maeda: Quantitation of nitric oxide using 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO). In Methods in Enzymology Vol. 268 (ed. L. Packer) Academic Press, N.Y., p. 211-221 (1996) 237.H. Maeda: Third phase in polymer drug development: SMANCS as a prototype model drug for cancer treatment. In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. (eds. N. Ogata, S.W. Kim, J. Feijen and T. Okano) Springer-Verlag, Tokyo, p. 101-105 (1996) 238.Y.-H. Shin, T. Akaike and H. Maeda: Therapeutic effects of the soybean trypsin inhibitor and its gelatin conjugate on the pseudomonal elastase induced shock in guinea pig. In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. (eds. N. Ogata, S.W. Kim, J. Feijen and T. Okano) Springer-Verlag, Tokyo, p. 339-340 (1996) 239.H. Maeda, Y.-H. Shin, T. Akaike and M. Yoshida: Setpic shock: Prevention by NO-scavenger (PTIO) and by kinin inhibitor. In SHOCK. From Molecular and Cellular Level to Whole Body (eds. K. Okada and H. Ogata) Elsevier Sciences B.V., Amsterdam, The Netherlands, p. 43-52 (1996) 240.H. Maeda: Pharmacological uniqueness and clinical effects of neocarzinostatin. : In Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug. (eds. H. Maeda, K. Edo and N. Ishida) Springer-Verlag, Tokyo, p. 205-226 (1996) 241.T. Akaike, K. Sato and H. Maeda: Activation of neocarzinostatin by NADPH/cytochrome P-450 reductase: Proposal of an ultimate mode of action in cells involving oxygen free radicals. In Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug. (eds. H. Maeda, K. Edo and N. Ishida) Springer-Verlag, Tokyo, p. 155-166 (1996) 242.H. Maeda and T. Konno: Metamorphosis of neocarzinostatin to SMANCS −Chemistry, pharmacology and clinical effect of the first prototype anticancer polymer therapeutic− In Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug. (eds. H. Maeda, K. Edo and N. Ishida) Springer-Verlag, Tokyo, p. 227-267 (1996) 243.K. Kuromizu and H. Maeda: Chemical structure of the apoprotein of neocarzinostatin. In Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug. (eds. H. Maeda, K. Edo and N. Ishida) Springer-Verlag, Tokyo, p. 3-22 (1996) 244.E. Masuda and H. Maeda: Host-mediated antitumor activity induced by neocarzinostatin and its polymer-conjugated derivative in tumor-bearing mice. In Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug. (eds. H. Maeda, K. Edo and N. Ishida) Springer-Verlag, Tokyo, p. 187-204 (1996)
245.T. Okamoto, T. Akaike, M. Suga, S. Tanase, H. Horie, S. Miyajima, M. Ando, Y. Ichinose and H. Maeda: Activation of human matrix metalloproteinases by various bacterial proteinases. J. Biol. Chem., 272, 6059-6066 (1997) 246.H. Muranaka, M. Suga, K. Sato, K. Nakagawa, T. Akaike, T. Okamoto, H. Maeda and M. Ando: Superoxide scavenging activity of erythromycin-iron complex. Biochem. Biophys. Res. Commun., 232, 183-187 (1997) 247.D.C. Hooper, O. Bagasra, J.C. Marini, A. Zborek, S.T. Ohnishi, R. Kean, J.M. Champion, A.B. Sarker, L. Bobroski, J.L. Farber, T. Akaike, H. Maeda and H. Koprowski: Prevention of experimental allergic encephalitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A., 94, 2528-2533 (1997) 248.T. Okamoto, T. Akaike, T. Nagano, S. Miyajima, M. Suga, M. Ando, K. Ichimori and H. Maeda: Activation of human neutrophil procollagenase by nitrogen dioxide and peroxynitrite: A novel mechanism for procollagenase activation involving nitric oxide. Arch. Biochem. Biophys., 342, 261-274 (1997) 249.T. Urakami, C. Yoshida, T. Akaike, H. Maeda, H. Nishigori and E. Niki: Synthesis of monoesters of pyrroloquinoline quinone and imidazopyrroloquinoline, and radical scavenging activities using electron spin resonance in vitro and pharmacological activity in vivo. J. Nutr. Sci. Vitaminol., 43, 19-33 (1997) 250.K. Umezawa, T. Akaike, S. Fujii, M. Suga, K. Setoguchi, A. Ozawa and H. Maeda: Induction of nitric oxide synthesis and xanthine oxidase and their role in the antimicrobial mechanism against Salmonella typhimurium in mice. Infect. Immun., 65, 2932-2940 (1997) 251.T. Akaike, K. Inoue, T. Okamoto, H. Nishino, M. Otagiri, S. Fujii and H. Maeda: Nanomolar quantification and identification of various nitrosothiols by high performance liquid chromatography coupled with flow reactors of metals and Griess reagent. J. Biochem., 122, 459-466 (1997) 252.K. Maruo, T. Akaike, T. Ono, T. Okamoto and H. Maeda: Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease. J. Allergy Clin. Immunol., 100, 253-260 (1997) 253.E. Masuda, T. Shishido, R. Fujimoto and H. Maeda: Changes in cellular composition induced by neocarzinostatin pretreatment in Meth A-bearing mice and the responsible antitumor effector cells. Immunopharmacology, 37, 105-116 (1997) 254.T. Hirano, T. Todoroki, R. Morita, S. Kato, Y. Ito, K.-H. Kim, P.G. Shukla, F. Veronese, H. Maeda and S. Ohashi: Anti-inflammatory effect of the conjugate of superoxide dismutase with the copolymer of divinyl ether and maleic anhydride against rat re-expansion pulmonary edema. J. Cont. Release, 48, 131-139 (1997) 255.H. Kojima, K. Sakurai, K. Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, H. Hirata, T. Akaike, H. Maeda and T. Nagano: Development of a fluorescent indicator for bioimaging of nitric oxide. Biol. Pharm. Bull., 20, 1229-1232 (1997) 256.K. Sato, T. Akaike, T. Sawa, Y. Miyamoto, M. Suga, M. Ando and H. Maeda: Nitric oxide generation from hydroxyurea via copper-catalyzed peroxidation and implications for pharmacological actions by hydroxyurea. Jpn. J. Cancer Res., 88, 1199-1204 (1997) 257.T. Oda, T. Konno, A. Nagamitsu, K. Tabaru, H. Maeda and N. Kitamura: Targeted vinblastine chemotherapy with two preparations of lipiodol contrast medium. Anticancer Res., 17, 3521-3530 (1997) 258.J. Jiang, S.J. Jordan, D.P. Barr, M.R. Gunther, H. Maeda and R.P. Mason: In vivo production of nitric oxide in rats after administration of hydroxyurea. Molecular Pharmacol., 52, 1081-1086 (1997) [Monograph] 259.H. Maeda: Review on the development of a polymer conjugate drugs: SMANCS. In Medicinal Chemistry: Today and Tomorrow (Proceedings of the AFMC International Medicinal Chemistry Symposium) (ed. M. Yamazaki) Blackwell Science Ltd., U.K., p. 197-204 (1997) 260.H. Maeda and Y. Kojima: Polymer-Drug Conjugates. In Desk Reference of Functional Polymers, Syntheses and Applications (ed. R. Arshady) American Chemical Society, Washington, D.C., p. 753-767 (1997) 261.H. Maeda and T. Akaike: Bacterial proteases as pathogenic factors in view of septicemia and shock. In Protease Inhibitors: Novel Therapeutic Application and Development (ed. N. Macready) International Business Communications, Inc., Southborough, Chapter 2.1, p. 1-33 (1997) 262.H. Maeda, T. Okamoto, T. Akaike, S. Miyajima, M. Suga, M. Ando and Y. Ichinose: Activation of matrix metalloproteinases by bacterial proteinases and pathogenic implication. In Medical Aspects of Proteases and Protease Inhibitors (eds. N. Katunuma, H. Kido, H. Fritz and J. Travis) IOS Press, Amsterdam, The Netherlands, p. 128-138 (1997) 263.K. Ebihara, Y. Yamagata, Y. Kumagae, T. Sato, T. Ikegami, Y. Kataoka and H. Maeda: Ozone and nitric monoxide production by high frequency silent discharge. In Proceedings of the 3rd International Conference on Reactive Plasmas and 14th Symposium Processing (eds. K. Tachibana and Y. Watanabe) Organizing Committee of ICRP-3/SPP-14, p. 194-195 (1997)
264.T. Akaike, M. Suga and H. Maeda: Free radicals in viral pathogenesis: Molecular mechanisms involving superoxide and NO. Proc. Soc. Exp. Biol. Med., 217, 64-73 (1998) 265.M. Yoshida, T. Akaike, S. Goto, W. Takahashi, A. Inadome, M. Yono, H. Seshita, H. Maeda and S. Ueda: Effect of the NO scavenger carboxy-PTIO on endothelium-dependent vasorelaxation of various blood vessels from rabbits. Life Sciences, 62, 203-211 (1998) 266.K. Maruo, T. Akaike, T. Ono and H. Maeda: Involvement of bradykinin generation in intravascular dissemination of Vibrio vulnificus and prevention of invasion by a bradykinin antagonist. Infect. Immun., 66, 866-869 (1998) 267.J. Wu, T. Akaike and H. Maeda: Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger. Cancer Res., 58, 159-165 (1998) 268.H. Maeda, T. Okamoto and T. Akaike: Human matrix metalloprotease activation by insults of bacterial infection involving proteases and free radicals. Biol. Chem., 379, 193-200 (1998) 269.Y. Noguchi, J. Wu, R. Duncan, J. Strohalm, K. Ulbrich, T. Akaike and H. Maeda: Early phase tumor accumulation of macromolecules: A great difference in clearance rate between tumor and normal tissues. Jpn. J. Cancer Res., 89, 307-314 (1998) 270.L.W. Seymour, S.P. Olliff, C.J. Poole, P.G. de Takats, R. Orme, D.R. Ferry, H. Maeda, T. Konno and D.J. Kerr: A novel dosage approach for evaluation of SMANCS [poly-(styrene-co-maleyl-half-n-butylate)-neocarzinostatin] in the treatment of primary hepatocellular carcinoma. Int'l J. Oncology, 12, 1217-1223 (1998) 271.K. Sato, M. Suga, T. Akaike, S. Fujii, H. Muranaka, T. Doi, H. Maeda and M. Ando: Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice. Am. J. Respir. Crit. Care Med., 157, 853-857 (1998) 272.H. Maeda and T. Akaike: Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Moscow), 63, (No.7) 1007-1017 (1998) 273.M. Kimura, T. Konno, Y. Miyamoto, Y. Kojima and H. Maeda: Intracavitary administration: Pharmacokinetic advantages of macromolecular anticancer agents against peritoneal and pleural carcinomatoses. Anticancer Res., 18, 2547-2550 (1998) 274.T. Sawa, T. Akaike, K. Kida, Y. Fukushima, K. Takagi and H. Maeda: Lipid peroxyl radicals from oxidized oils and heme-iron: Implication of a high-fat diet in colon carcinogenesis. Cancer Epidemiology, Biomarkers & Prevention, 7, 1007-1012 (1998) 275.M. Yoshida, T. Akaike, A. Inadome, W. Takahashi, H. Seshita, M. Yono, S. Goto, H. Maeda and S. Ueda: The possible effect of nitric oxide on relaxation and noradrenaline release in the isolated rabbit urethra. Eur. J. Pharmacol., 357, 213-219 (1998) 276.N. Nakatsubo, H. Kojima, K. Sakurai, K. Kikuchi, H. Nagoshi, Y. Hirata, T. Akaike, H. Maeda, Y. Urano, T. Higuchi and T. Nagano: Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors. Biol. Pharm. Bull., 21, 1247-1250 (1998) [Monograph] 277.H. Maeda and T. Akaike: Infection, inflammation and cancer mediated by oxygen radicals and nitric oxide. In Nitric Oxide in Allograft Rejection and antitumor Responses (eds. S.J. Lukiewicz and J.L. Zweier) Kluwer Academic Publishers, Norwell, p. 277-294 (1998) 278.T. Akaike, K. Inoue, T. Okamoto, Y. Miyamoto and H. Maeda: Specific and sensitive quantitation of various nitrosothiols by high performance liquid chromatography coupled with flow reactor systems. In The Biology of Nitric Oxide Part 6 (Proceedings of the 5th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, N. Toda, H. Maeda and E.A. Higgs) Portland Press Ltd., London, p. 45-46 (1998) 279.T. Okamoto, T. Akaike, M. Suga, H. Maeda and M. Ando: Redox-based remodeling of extracellular matrix by matrix metalloproteinases involving peroxynitrite and glutathione. In The Biology of Nitric Oxide Part 6 (Proceedings of the 5th International Meeting on the Biology of Nitric Oxide) (eds. SS. Moncada, N. Toda, H. Maeda and E.A. Higgs) Portland Press Ltd., London, p. 283 (1998) 280.K. Doi, T. Akaike, S. Fujii, N. Ikebe, T. Beppu, M. Ogawa, S. Shibahara and H, Maeda: Induction of heme oxygenase and nitric oxide synthase in an experimental solid tumor in rats. In The Biology of Nitric Oxide Part 6 (Proceedings of the 5th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, N. Toda, H. Maeda and E.A. Higgs) Portland Press Ltd., London, p. 187 (1998) 281.S. Tayama, T. Akaike, R. Tsunoda, C.G. Li, M. Yoshida, H. Yasue and H, Maeda: Characterization of EDRF response by using liposome PTIO in vitro and in vivo: Implication of nitrosothiol formation to EDRF response. In The Biology of Nitric Oxide Part 6 (Proceedings of the 5th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, N. Toda, H. Maeda and E.A. Higgs) Portland Press Ltd., London, p. 311 (1998) 282.E. Akizuki, T. Akaike, Y. Yamaguchi, Y. Miyamoto, H. Maeda and M. Ogawa: Role of NO and superoxide in injury of cardiac allografts transplanted in rats. In The Biology of Nitric Oxide Part 6 (Proceedings of the 5th International Meeting on the Biology of Nitric Oxide), (eds. S. Moncada, N. Toda, H. Maeda and E.A. Higgs) Portland Press Ltd., London, p. 213 (1998) 283.S. Fujii, T. Akaike and H, Maeda: In The Biology of Nitric Oxide Part 6 (Proceedings of the 5th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, N. Toda, H. Maeda and E.A. Higgs), p. 18 (1998) Role of nitric oxide in the pathogenesis of herpes simplex virus encephalitis in rats. Portland Press Ltd., London 284.C.G. Li, M.J. Rand, T. Akaike, M. Yoshida and H. Maeda: In The Biology of Nitric Oxide Part 6 (Proceedings of the 5th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, N. Toda, H. Maeda and E.A. Higgs), p. 80 (1998) Activation of nitrergic mechanism by black widow spider venom and a-latrotoxin. Portland Press Ltd., London
285.T. Sawa, M. Nakao, T. Akaike, K. Ono and H. Maeda: Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: Implications for the antitumor-promoter effect of vegetables. J. Agric. Fd. Chem., 42, 397-402 (1999) 287.R.E. Glover, E.D. Ivy, E.P. Orringer,H. Maeda and R.P. Mason: Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea. Mol. Pharmacol., 55, 1006-1010 (1999) 288.H. Sugiura, M. Ichinose, T. Oyake, Y. Mashito, Y. Ohuchi, N. Endoh, M. Miura, S. Yamagata, A. Koarai, T. Akaike, H. Maeda and K. Shirato: Role of peroxynitrite in airway microvascular hyperpermeability during late allergic phase in guinea pigs. Am. J. Respir. Crit. Care Med., 160, 663-671 (1999) 289.K. Iwasaki, Q. Wang, N. Satoh, S. Yoshida, T. Akaike, K. Sekizawa, H. Maeda and H. Sasaki: Effects of qing fei tang (TJ-90) on aspiration pneumonia in mice. Phytomedicine, 6, 95-101 (1999) 290.K. Doi, T. Akaike, S. Fujii, S. Tanaka, N. Ikebe, T. Beppu, S. Shibahara, M. Ogawa and H. Maeda: Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth. Br. J. Cancer, 80, 1945-1954 (1999) 291.K. Inoue, T. Akaike, Y. Miyamoto, T. Okamoto, T. Sawa, M. Otagiri, S. Suzuki, T. Yoshimura and H. Maeda: Nitrosothiol formation catalyzed by ceruloplasmin: Implication for cytoprotective mechanism in vivo. J. Biol. Chem., 274, 27069-27075 (1999) 292.K. Iwasaki, T. Ohrui, Q. Wang, K. Sekizawa, T. Akaike, H. Maeda and H. Sasaki: Combined effects of both bacteria and gastric juice on pneumonia in mice. Respir. Physiol., 116, 201-209 (1999) 293.H. Maeda, T. Sawa, T. Yubisui and T. Akaike: Free radical generation from heterocyclic amines by cytochrome b5 reductase in the presence of NADH. Cancer Letters, 143, 117-121 (1999) 294.Y. Suzuki, S. Fujii, T. Tominaga, T. Yoshimoto, S. Fujii, T. Akaike, H. Maeda and T. Yoshimura: Direct evidence of in vivo nitric oxide production and inducible nitric oxide synthase mRNA expression in the brain of living rat during experimental meningitis. J. Cereb. Blood Flow Metab.,19, 1175-1178 (1999) 295.H. Maeda, J. Wu, T. Okamoto, K. Maruo and T. AkaikeKallikrein-kinin in infection and cancer. Immunopharmacology, 43, 115-128 (1999) [Monograph] 296.T. Akaike and H. Maeda: Nitric oxide in influenza. In Nitric Oxide and Infection (ed. F.C. Fang) Kluwer Academic/Plenum Publishing Co., New York, p. 397-415 (1999) 297.H. Maeda: Generation of lipid peroxyl radicals from edible oils and their biological activities: basic research for edible oils with anti-radical activity. In Nestle Science Promotion Committee Annual Report (eds. T. Fujii, C. Machida and S. Yano), p. 97-102 (1999)
298.Y. Miyamoto, T. Akaike, M. Samiul Alam, K. Inoue, T. Hamamoto, N. Ikebe, J. Yoshitake, T. Okamoto and H. Maeda: Novel functions of human a1-protease inhibitor after S-nitrosylation: Inhibition of cysteine protease and antibacterial activity. Biochem. Biophys. Res. Commun., 267, 918-923 (2000) 299.T. Akaike, S. Fujii, A. Kato, J. Yoshitake, Y. Miyamoto, T. Sawa, S. Okamoto, M. Suga, M. Asakawa, Y. Nagai and H. Maeda: Viral mutation accelerated by nitric oxide production during infection in vivo. FASEB J., 14, 1447-1454 (2000) 300.T. Sawa, J. Wu, T. Akaike and H. Maeda: Tumor-targeting chemotherapy by a xanthine oxidase-polymer conjugate that generates oxygen-free radicals in tumor tissue. Cancer Res., 60, 666-671 (2000) 301.K. Hori, S. Saito, H. Takahashi, H. Sato, H. Maeda and Y. Sato: Tumor-selective blood flow decrease induced by an angiotensin converting enzyme inhibitor, temocapril hydrochloride. Jpn. J. Cancer Res., 91, 261-269 (2000) 302.H. Maeda, J. Wu, T. Sawa, Y. Matsumura and K. Hori: [Review] Tumor vascular permeability and the EPR effect in macromolecular therapeutics. J. Cont. Release, 65, 271-284 (2000) 303.Y. Miyamoto, T. Akaike and H. Maeda: S-Nitrosylated human a1-protease inhibitor. Biochim. Biophys. Acta, 1477, 90-97 (2000) 304.A. Kanazawa, T. Sawa, T. Akaike and H. Maeda: Formation of abasic sites in DNA by t-butyl peroxyl radicals: implication for potent genotoxicity of lipid peroxyl radicals. Cancer Letters, 156, 51-55 (2000) 305.K. Tsuchiya, T. Uchida, M. Kobayashi, H. Maeda, T. Konno and H. Yamanaka: Long-term survival rate after tumor-targeted chemotherapy with the macromolecular anticancer drug SMANCS in lipid contrast medium for renal cell carcinoma: Preoperative therapy for nonmetastatic cases. Urology, 55, 495-500 (2000) 306.H. Kuwahara, Y. Miyamoto, T. Akaike, T. Kubota, T. Sawa, S. Okamoto and H. Maeda: Helicobacter pylori urease suppresses bactericidal activity of peroxynitrite via carbon dioxide production. Infect. Immun., 68, 4378-4383 (2000) 307.T. Sawa, T. Akaike and H. Maeda: Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase. J. Biol. Chem., 275, 32467-32474 (2000) 308.E. Akizuki, T. Akaike, S. Okamoto, S. Fujii, Y. Yamaguchi, M. Ogawa and H. Maeda: Role of nitric oxide and superoxide in acute cardiac allograft rejection in rats. Proc. Soc. Exp. Biol. Med., 225, 151-159 (2000) 309.N. Ikebe, T. Akaike, Y. Miyamoto, K. Hayashida, J. Yoshitake, M. Ogawa and H. Maeda: Protective effect of S-nitroso-a1-protease inhibitor on hepatic ischemia-reperfusion injury. J. Pharmacol. Exp. Ther., 295, 904-911 (2000) 310.T. Akaike, and H. Maeda: Nitric oxide and virus infection. Immunology, 101, 300-308 (2000) 311.A. Kanazawa, T. Sawa, T. Akaike, S. Morimura, K. Kida, and H. Maeda: Generation of lipid peroxyl radicals from edible oils and their biological activities: A need for consideration for anti-radical components and purification processing. BioFactors, 13, 187-193 (2000) [Monograph] 312.Y. Miyamoto, T. Akaike and H. Maeda: Bioassay for antioxidant activity: Determination of scavenging capacity of antioxidants against lipid peroxyl radicals. In Experimental Protocols for Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) (eds. N. Taniguchi and J.M.C. Gutteridge) Oxford University Press, New York, Oxford, p. 45-49 (2000) 313.T. Akaike and H. Maeda: Pathophysiological effects of high-output production of nitric oxide. In Nitric Oxide (ed. L.J. Ignarro) Academic Press, San Diego, p.733-745 (2000) 314.H. Maeda, J. Wu, A. Okuyama and T. Akaike: Vascular permeability enhancement by peroxynitrite involving activation of collagenase followed by subsequent protease cascade leading to bradykinin generation in tumor. In The Biology of Nitric Oxide Part 7 (Proceedings of the 6th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, L. Gustafsson, P. Wiklund and E.A. Higgs) Portland Press Ltd., London, p. 204 (2000) 315.T. Akaike and H. Maeda: Viral mutation and evolution accelerated by nitric oxide-induced oxidative stress. In The Biology of Nitric Oxide Part 7 (Proceedings of the 6th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, L. Gustafsson, P. Wiklund and E.A. Higgs) Portland Press Ltd., London, p. 16 (2000) 316.Y. Miyamoto, T. Akaike, H. Kuwahara, T. Kubota, S. Yoshimatsu, T. Sawa, S. Okamoto and H. Maeda: Urease functions as a defense system of Helicobacter pylori against peroxynitrite through the production of carbon dioxide. In The Biology of Nitric Oxide Part 7 (Proceedings of the 6th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, L. Gustafsson, P. Wiklund and E.A. Higgs) Portland Press Ltd., London, p. 30 (2000) 317.T. Sawa, T. Akaike and H. Maeda: Tyrosine nitration by peroxynitrite generated from xanthine oxidase-hypoxanthine and nitric oxide. In The Biology of Nitric Oxide Part 7 (Proceedings of the 6th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, L. Gustafsson, P. Wiklund and E.A. Higgs) Portland Press Ltd., London, p. 174 (2000) 318.N. Ikebe, T. Akaike, Y. Miyamoto, M. Ogawa and H. Maeda: Protective effect of S-nitroso-a1-protease inhibitor on hepatic ischemia-reperfusion injury. In The Biology of Nitric Oxide Part 7 (Proceedings of the 6th International Meeting on the Biology of Nitric Oxide) (eds. S. Moncada, L. Gustafsson, P. Wiklund and E.A. Higgs) Portland Press Ltd., London, p. 51 (2000) 319.H. Maeda and T. Sawa: Free radical generating polymer conjugates for cancer therapy as a new tactics: Poly(ethylene glycol) conjugated xanthine oxidase. In Biomaterials and Drug Delivery toward New Millenium (eds. K.D. Park, I.C. Kwon, N. Yui, S.Y. Jeong and K. Park) Han Rim Won Publishing Co. Seoul, p. 333-344 (2000)
320.H. Maeda: SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv. Drug Delivery Reviews., 46, 169-185 (2001) 321.H. Maeda, T. Sawa, and T. Konno: Mechanism of tumor-targeted deliverly of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. J. Cont. Release, 74, 47-61 (2001) 322.J. Wu, T. Akaike, K. Hayashida, T. Okamoto, A. Okuyama, and H. Maeda: Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinase. Jpn. J. Cancer Res., 92, 439-451 (2001) 323.T. Okamoto, T. Akaike, T. Sawa, Y. Miyamoto, Albert van der Vliet, and H. Maeda: Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation. J. Biol. Chem., 276, 29596-29602 (2001) 324.S. Miyajima, T. Akaike, K. Matsumoto, T. Okamoto, J. Yoshitake, K. Hayashida, A. Negi and H. Maeda: Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro. Microbial Pathogenesis , 31, 271-281 (2001) [Monograph] 325.A. Kanazawa, T. Sawa, T Akaike and H. Maeda: Generation of lipid peroxyl radicals from oxidized edible oils and heme-iron. In Free Radicals in Foods: Chemistry, Nutrition and Health (eds. M. Morello and F, Shahidi) ACS book, Am. Chem. Soc., Washington, D.C., p. 282-300 (2001) 326.H. Maeda: The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting. In Advances in Enzyme Regulation (eds. George Weber M.D.) Elsevier Science Ltd., Oxford, UK., 41, 189-207 (2001)
327.J. Wu, T. Akaike, K. Hayashida, Y. miyamoto, T. Nakagawa, K. Miyakawa, W. Muller-Esterl and H. Maeda: Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues. Int. J. Cancer, 98, 29-35 (2002) 328.J. Fang, T. Sawa, T. Akaike and H. Maeda: Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer Res., 62, 3138-3143 (2002) 329.S.K.Sahoo, T. Sawa, J. Fang, S. Tanaka, Y. Miyamoto, T. Akaike, and H. Maeda: Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity. Bioconj. Chem., 13, 1031-1038 (2002) 330.A. Kanazawa, T. Sawa, T. Akaike, and H. Maeda: Dietary lipid peroxidatin products and DNA damage in colon carcinogenesis. Eur. J. Lipid Science Tech., 104, 439-447 (2002) 331.D. Kuruppu, C. Christophi, H. Maeda, and P. E. OfBrien: Changes in the microvascular architecture of colorectal liver metastases following the administration of SMANCS/Lipiodol. J. Surgical Res., 103, 47-54 (2002) 332.M. S. Alam, T. Akaike, S. Okamoto, T. Kubota, J. Yoshitake, T. Sawa, Y. Miyamoto, F. Tamura, and H. Maeda: Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect. Immun., 70, 3130-3142 (2002) [Monograph] 333.H. Maeda: Microbial proteinases and pathogenesis of infection. In The Encyclopedia of Molecular Medicine (eds. T. E. Creighton) John Wiley & Sons, Inc., New York, vol.4, p.2663-2668 (2002) 334.H. Maeda: Enhanced permeability and retention (EPR) effect: Basis for drug targeting to tumor. In Biomedical Aspect of Drug Targeting (eds. V. Muzykantov and V. Torchilin) Kluwer Publishers, Massachusetts, Chap. 11, p.211-228 (2002)
335.S. Tanaka, T. Akaike, J. Fang, T. Beppu, M. Ogawa, F. Tamura, Y. Miyamoto and H. Maeda: Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour. Br. J. Cancer, 88, 902-909 (2003) 336.H. Maeda, J. Fang, T. Inuzuka, and Y. Kitamoto: Vascular permeability enhancement in solid tumor: Various factors, mechanisms involved and its implications. Intfl Immunopharmacology, 3, 319-328 (2003) 337.T. Akaike, S. Okamoto, T. Sawa, J. Yoshitake, F. Tamura, K. Ichimori, K. Miyazaki, K. Sasamoto and H. Maeda: 8-Nitroguanosine formation in viral pneumonia and its implication for pathogenesis. Proc. Natl. Acad. Sci. U.S.A, 100, 685-690 (2003) 338.S. Tanaka, T. Akaike, S. J. Wu, J. Fang, T. Sawa, M. Ogawa, T. Beppu and H. Maeda: Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin I2 analogue beraprost sodium. J. Drug Targeting, 11, 45-52 (2003). 339.J. Fang, T. Sawa, T. Akaike, T. Akuta, K. Greish, A. Hamada and H. Maeda: In vivo, antitumor activity of pegylated zinc protoporphyrin: Targeted inhibition of heme oxygenase in solid tumor. Cancer Res., 63, 3567-3574 (2003) 340.K. Greish, J. Fang, T. Inuzuka, A. Nagamitsu and H. Maeda: Macromolecular anticancer therapeutics for effective solid tumor targeting: Advantages and prospects. Clinical Pharmacokinetics, 42, 1089-1105 (2003) 341.K. Morikawa, T. Matoba, H. Kubota, T. Akaike, M. Talukder, I. Kunihiro, M. Motoishi, M. Hatanaka, T. Fujiki, H. Maeda, S. Takahashi, A. Takeshita, and H. Shimokawa: Pivotal role of Cu, Zn-SOD in endothelium-dependent hyperpolarization. J. Clin. Invest., 112, 1871-1879 (2003) 342.T. Sawa, T. Akaike, K. Ichimori, T. Akuta, K. Kaneko, H. Nakayama, D. Stuehr, and H. Maeda. Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative. Biochem. Biophys. Res. Comm., 311, 300-306 (2003) [Monograph] 343.J. Fang, T. Sawa, and H. Maeda: Factors and mechanism of gEPRh effect and enhanced antitumor effects of macromolecular drugs including SMANCS. In Polymer Drugs in Clinical Stage: Advantages and Prospects (eds. H. Maeda et al.) Kluwer Academic/Plenum Publishers, London, Chap. 2, 29-49 (2003) 344.T. Sawa, S. K. Sahoo, and H. Maeda: Water soluble polymers in medicine; Polymer-drug conjugates in chemotherapy. In PBM Series Vol. 1/Introduction to Polymeric Biomaterials (ed. R. Arshady), Citus Books, London, Chap. 7, 233-261 (2003)
345.J. Fang, T. Sawa, T. Akaike, K. Greish, and H. Maeda: Enhanced chemotherapeutic effect against tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin in combination with anticancer agents. Int. J. Cancer, 109, 1-8 (2004) 346.J. Fang, T. Akaike, and H. Maeda: Antiapoptotic role of heme oxygenase and its potential as an anticancer target. Apoptosis, 9, 27-35 (2004) 347.K. Greish, T. Sawa, J. Fang, T. Akaike and H. Maeda: SMA- doxorubicin, a new polymeric micellar drug for effective anticancer targeting. J. Cont. Release, 97, 219-230 (2004) 348.H. Kuwahara, A. Kanazawa, D. Wakamatsu, S. Morimura, K. Kida, T. Akaike, and H. Maeda: Antioxidative and antimutagenic activities of 4-vinyl-2, 6-dimethoxyphenol (canolol) isolated from canola oil. J. Agric. Fd. Chem., 52, 4380-4387 (2004) 349.F. Tamura, R. Nakagawa, T. Akuta, S. Okamoto, S. Hamada, H. Maeda, S. Kawabata and T. Akaike: Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B). Infect. Immun., 72, 4836-4847 (2004) 350.J. Yoshitake, T. Akaike, T. Akuta, F. Tamura, T. Ogura, H. Esumi and H. Maeda: Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity. J. Virol., 78, 8709-8719 (2004) @ |
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