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Research

Achievements

2012

  1. Maeda H.
    Macromolecular therapeutics in cancer treatment: the EPR effect and beyond.
    J Control Release. 2012 164(2):138-44.
  2. D. Iohara, K. Yoshida, K. Yamaguchi, M. Anraku, K. Motoyama, H. Arima, K. Uekama and F. Hirayama.
    Cyclodextrin-induced Change in Crystal Habit of Acetylsalicylic Acid in Aqueous Solution.
    Cryst. Growth Des., 12(4), 1985-1991 (2012).
  3. M. Anraku, H. Tomida, A. Michihara, D. Tsuchiya, D. Iohara, Y. Maezaki, K. Uekama, T. Maruyama, M. Otagiri and F. Hirayama.
    Antioxidant and Renoprotective Activity of Chitosan in Nephrectomized Rats.
    Carbohydr. Polym., 89, 302-304 (2012).
  4. H. Arima, M. Arizono, T. Higashi, A. Yoshimatsu, H. Ikeda, K. Motoyama, K. Hattori, T. Takeuchi, F. Hirayama and K. Uekama.
    Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with a-Cyclodextrin as DNA Carriers to Tumor Cells.
    Cancer Gene Ther., 19(5), 358-366 (2012).
  5. T. Anno, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama and H. Arima.
    Possible Enhancing Mechanisms for Gene Transfer Activity of Glucuronylglucosyl-β-cyclodextrin/dendrimer Conjugate (G2).
    Int. J. Pharm., 426(1-2), 239-247 (2012).
  6. D. Iohara, M. Hiratsuka, F. Hirayama, K. Takeshita, K. Motoyama, H. Arima and K. Uekama.
    Evaluation of photodynamic activity of C60/2-hydroxypropyl-β-cyclodextrin nanoparticles.
    J. Pharm. Sci.,101(9), 3390-3397 (2012).
  7. T. Anno, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama and H. Arima.
    Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a DNA carrier in vitro and in vivo.
    J. Drug Target., 20(3), 272-280 (2012).
  8. K. Uehata, T. Anno, K. Hayashida, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama and H. Arima.
    Peak-less Hypoglycemic Effect of Insulin Glargine by Complexation with Maltosyl-β-cyclodextrin.
    Int. J. Pharm., 422(1-2), 33-39 (2012).
  9. 上釜兼人
    シクロデキストリンを基盤にした新規製剤設計へのアプローチ
    薬学雑誌, 132,(1), 85-105 (2012).
  10. 有馬英俊、本山敬一、東 大志、上釜兼人
    シクロデキストリンを用いた難水溶性薬物の溶解性ならびに吸収性の改善, "難吸収性薬物の吸収性改善と新規投与製剤の開発"
    山本 昌（監修）,　シーエムシー出版, Tokyo, 2012, pp. 8-17.
  11. 本山敬一、東 大志、平山文俊、上釜兼人、有馬英俊
    シクロデキストリンポリシュードロタキサンを用いたタンパク質・遺伝子徐放システム
    PHARM TECH JAPAN,28(10), 169-177 (2012).
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