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Introduction

Faculty of Pharmaceutical Sciences, Sojo University was established in 2005. Now we apply 6-year program which includes long-term clerkship to educate specialists of medicines and medications. The aim of the faculty is to cultivate pharmacists who will be pivotal members in medical team or pharmaceutical industry. Therefore, we are responsible for developing their knowledge, skill and manner as professional pharmacists through our educations. We also focus on the researches not only to develop new medicines and medications but also research mind of pharmacists. Researches are performed in 19 laboratories and DDS (Drug Delivery System) research center. Join us, and set your sights on becoming high quality pharmacists in Sojo University.

Divisions & Laboratories

Clinical Pharmaceutics Physical Pharmaceutics Clinical Pharmacology & Therapeutics Pharmacy Practice Biopharmaceutics Pharmaceutical Informatics Biological Chemistry Pharmacology Molecular Cell Pharmacology Microbiology & Oncology Hygienic Chemistry Environmental Science & Technology Biophysical Chemistry Analytical Chemistry Organic Chemistry Molecular Design Pharmacognosy Medical Plant Garden

Clinical Pharmacy

Clinical Pharmaceutics

Research

  1. Evaluation of antioxidant activity of medicine and application of kidney disease
  2. Optimization of drug dosing in CKD patients
  3. Pharmacokinetic analysis of antiviral drugs

Staff

Professor: Daisuke Kadowaki, PhD
Assistant Professor: Mai Hashimoto, PhD

Physical Pharmaceutics

Research

  1. Improvement of various pharmaceutical properties of drug molecules by hydrophilic CyDs
  2. Control of polymorphic transitions of drug molecules by methylated CyDs
  3. Development and application of chitosan derivative in the pharmaceutical fields
  4. Design and evaluation of hydrophilic C60 nanoparticles by cyclodextrins

Staff

Professor: Makoto Anraku, PhD
Associate Professor: Daisuke Iohara, PhD
Professor (Specially Appointed): Fumitoshi Hirayama, PhD

Link

http://www.ph.sojo-u.ac.jp/~dio/indexE.html

Clinical Pharmacology & Therapeutics

Research

  1. Research on medical pharmacology
  2. Research on pharmaceutical Education

Staff

Professor: Yuji Uchida, MD, PhD
Associate Professor: Tokunori Ikeda, MD, PhD
Assistant Professor: Fukuko Horio, PhD

Pharmacy Practice

Research

  1. Analysis of adverse drug reaction using drug information database.
  2. Studies on applying cyclodextrin to medicinal area.
  3. Therapeutic drug monitoring of various drugs.

Staff

Professor: Shigeyuki Miyamura, PhD
Associate Professor: Takako Ishiguro, PhD
Senior Assistant Professor: Kenshiro Hirata, PhD

Biopharmaceutics

Research

Our laboratory’s research embraces the principle of practicality where basic scientific information gathered from the in vitro experiments will feedback to the clinical applications, and vice versa. In other words, “from bench site to the clinical wards E Our research efforts and achievements can be categorized under the following three themes:

  1. Pharmaceutical characterization of drug disposition;
  2. Development of drug delivery system (DDS) using protein based carriers
  3. Development of chemotherapy based on tumor specific characteristics
  4. Evidence based clinical applications.

Staff

Professor: Keishi Yamasaki, PhD
Associate Professor: Koji Nishi, PhD
Assistant Professor: Kenji Tsukigawa, PhD
Professor (Specially Appointed): Masaki Otagiri,PhD

Pharmaceutical Informatics

Research

  1. Study on pharmaceutical informatics to promote gender-specific medicine based by pharmacology

Staff

Professor: Mihoko Nakashima, PhD

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Life Science

Biological Chemistry

Research

Snake venom is a unique cocktail of more than 100 different proteins with a wide variety of pharmacological activities, and have evolved in an accelerated manner. Such accelerated evolution has rarely been known for general isozymes. In addtion, it has been recently found that Protobothrops flavoviridis species (Habu snake) isolated in separate islands over a long period have undergone island specific changes in the genes of venom isozymes. We have been attracted to such snake venom or venomous system and have been doing various biological research as mentioned above.

  1. Structure-function studies of novel bioactive proteins from snake venoms.
  2. Elucidation of molecular mechanisms of transcriptional regulation in snake venom gland.
  3. Venomics project (genomics, transcriptomics and proteomics) of Habu snake (Protobothrops flavoviridis)
  4. Engineering of therapeutic antibody fragment.

Staff

Professor: Naoko Oda-Ueda, PhD
Professor: Takatoshi Ohkuri, PhD
Senior Assistant Professor: Hitomi Nakamura, PhD

Pharmacology

Research

  1. Application of Bioelectronics in Physiology and Pharmacology
  2. A novel therapy using phosphodiesterase(PDE) inhibitors for chronic inflammatory diseases
  3. Investigation of the regulatory mechanism of SIGIRR expression, a negative regulator of Toll like receptor signaling

Staff

Professor: Naofumi Tokutomi, PhD
Senior Assistant Professor: Keiko Shuto, PhD

Molecular Cell Pharmacology

Research

  1. Development of peptidomimetic probes for tumor cell death
  2. Molecular function of nucleoporins in diseases
  3. Development of MRI-techniques in neurodegenerative diseases

Staff

Professor: Akihiko Kuniyasu, PhD
Associate Professor: Masaki Makise, PhD

Microbiology & Oncology

Research

  1. Development of preventative and therapeutic agents for herpetic disease.
  2. Development of preventative and therapeutic agents for infectious nonbacterial gastroenteritis.
  3. Antitumor effect of micelles of zinc protoporphyrin congated to styrene maleic acid anhydride (SMA) copolymer.
  4. Combinational effect of antitumor drug and heme oxygenase-1(OH-1) inhibitor.
  5. Micelles of zinc protoporphyrin congated to N-(2-hydroxypropyl)methacrylamide(HPMA) copolymer for imaging and light-induced antitumor effect.

Staff

Professor: Kazumi Yokomizo, PhD
Associate Professor: Jun Fang, MD
Senior Assistant Professor: Jian-Rong Zhou, PhD

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Hygienic Science

Hygienic Chemistry

Research

  1. Oxidative stress on human health
  2. Evaluation of the toxicity of dihydropyrazine (DHP) derivatives
  3. Analysis of a role of the zinc transporter in oxidative stress

Staff

Professor: Shinji Takechi, PhD
Senior Assistant Professor: Yuu Miyauchi, PhD

Environmental Science & Technology

Research

  1. Development of selenium-dependent glutathione peroxidase mimics
  2. Development of liposomal anti-cancer drug delivery systems
  3. Development of selenophene-based polymeric drug carrier

Staff

Professor: Mamoru Haratake, PhD
Senior Assistant Professor: Hideaki Nakamura, PhD

Biophysical Chemistry

Research

  1. Molecular structure analysis with X-ray crystallography and molecular modeling
  2. Estimation of diffusion coefficients based on experiments and molecular modeling

Staff

Professor: Shuichi Miyamoto, PhD
Professor: Kazumi Shimono, PhD

Analytical Chemistry

Research

  1. Non-invasive measurement of redox state with ESR-spin probe technique and analysis of the relation of the redox state to pathological condition
  2. Development of multi-functional contrast agents for MRI/ESR imaging toward the fusion of diagnosis and therapy (theranostics)
  3. Application of MRI/ESR to analysis of pharmacokinetics
  4. Analysis of photo-induced radical reactions related to side effects of drugs
  5. Development of sensitive method to measure reactive oxygen species using chemiluminescence technique

Staff

Professor: Keizo Takeshita, PhD
Associate Professor: Shoko Okazaki, PhD
Assistant Professor: Yuhei Ota, PhD

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Medicinal Chemistry

Organic Chemistry

Research

  1. Mechanistic studies of new catalyses
  2. The chemistry of indium in its low-oxidation state
  3. Design and Synthesis of Novel Nucleotide Analogs as Anti HBV Agents
  4. Site Specific DNA/RNA Modification by Artificial Nucleobase

Staff

Associate Professor: Hisao Kansui, PhD
Associate Professor: Shuhei Imoto, PhD

Molecular Design

Research

  1. Molecular design using cascade reactions
  2. Isolation and structure analysis of atropisomers
  3. Catalytic activation of boron reagents by hydroxycarboxylic acids
  4. New synthetic reactions using Lewis base catalysts and silicon reagents
  5. Metal-catalyzed selective functionalizations of polyols
  6. Synthesis of biologically active compounds by TiCl4-promoted aldol condensation
  7. Synthesis of antiviral molecules

Staff

Professor: Masaharu Sugiura, PhD
Associate Professor: Koki Yamaguchi, PhD

Pharmacognosy

Research

  1. Study on isoflavone glycosides from Fabaceae plants inhibit the cancer cell growth
  2. Evaluation of the immunosuppressive activity by using cycloartane glycosides in the Ranunculaceae plants
  3. Study on prenylated flavonoids from Epimedium herba inhibit the formation of advanced glycation end-products
  4. Effect of triterpenoids contained in Rosaceae plants on macrophage activation

Staff

Professor: Hitoshi Yoshimitsu, PhD
Associate Professor: Hiroyuki Miyashita, PhD

Medical Plant Garden

Research

  1. Study on natural products having the inhibition activity of Advanced Glycation End products
  2. Research on natural materials to prevent periodontal disease
  3. Development research as a nano material for tomato components

Staff

Professor: Tsuyoshi Ikeda, PhD
Technical officer: Sachio Honnda

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