Faculty of Pharmaceutical Sciences, Sojo University was established in 2005. Now we apply 6-year program which includes long-term clerkship to educate specialists of medicines and medications. The aim of the faculty is to cultivate pharmacists who will be pivotal members in medical team or pharmaceutical industry. Therefore, we are responsible for developing their knowledge, skill and manner as professional pharmacists through our educations. We also focus on the researches not only to develop new medicines and medications but also research mind of pharmacists. Researches are performed in 19 laboratories and DDS (Drug Delivery System) research center. Join us, and set your sights on becoming high quality pharmacists in Sojo University.
- Quality evaluation of generic medicines and supplements
- Clinical application of Color Universal Design (CUD)
- Analysis of the factors influencing pharmacokinetics in disease state and their clinical relevance
Professor: Hakaru Seo, PhD
Professor: Keishi Yamasaki, PhD
Assistant Professor: Kazuaki Taguchi, PhD
- Improvement of various pharmaceutical properties of drug molecules by hydrophilic CyDs
- Control of polymorphic transitions of drug molecules by methylated CyDs
- Development and application of chitosan derivative in the pharmaceutical fields
- Design and evaluation of hydrophilic C60 nanoparticles by cyclodextrins
Professor: Fumitoshi Hirayama, PhD
Associate Professor: Makoto Anraku, PhD
Assistant Professor: Daisuke Iohara, PhD
Clinical Pharmacology & Therapeutics
- Regenerative Medicine in Muscular Diseases: Generation of Muscle from Fibroblast using Adenoviral and Lentiviral Vectors
- Regenerative Medicine in Muscular Diseases: Generation of Muscle from iPS cells using Adenoviral and Lentiviral Vectors
- Herbal Medicine from Sea Weed for Diabetes Mellitus
- Educational Approach for Resuscitation and Clinical Assessmet
Professor: Makoto Matsukura, M.D., Ph.D.
Associate Professor: Isao Fujii, M.D., Ph.D.
- Study on evaluation of proper use of medicines
- Studies on disaster medicine
- Studies on pharmacist work in foreign countries
- Studies on drug-induced diseases
- Studies on applying cyclodextrin to medicinal area
Professor: Satoshi Tsuruta, PhD
Associate Professor: Hiroshi Moriuchi, PhD
Lectureｒ: Takako Ishiguro, PhD
Our laboratory’s research embraces the principle of practicality where basic scientific information gathered from the in vitro experiments will feedback to the clinical applications, and vice versa. In other words, “from bench site to the clinical wards”. Our research efforts and achievements can be categorized under the following three themes:
- Pharmaceutical characterization of drug disposition;
- Drug delivery system development; and
- Evidence based clinical applications.
Professor: Masaki Otagiri,PhD
- Study on pharmaceutical informatics to promote gender-specific medicine based by pharmacology
Professor: Mihoko Nakashima, PhD
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Snake venom is a unique cocktail of more than 100 different proteins with a wide variety of pharmacological activities, and have evolved in an accelerated manner. Such accelerated evolution has rarely been known for general isozymes. In addtion, it has been recently found that Protobothrops flavoviridis species (Habu snake) isolated in separate islands over a long period have undergone island specific changes in the genes of venom isozymes. We have been attracted to such snake venom or venomous system and have been doing various biological research as mentioned above.
- Structure-function studies of novel bioactive proteins from snake venoms.
- Elucidation of molecular mechanisms of transcriptional regulation in snake venom gland.
- Venomics project (genomics, transcriptomics and proteomics) of Habu snake (Protobothrops flavoviridis)
- Engineering of therapeutic antibody fragment.
Professor: Naoko Oda-Ueda, PhD
Professor: Takatoshi Ohkuri, PhD
Research Associate: Hitomi Nakamura,MS
- Application of Bioelectronics in Physiology and Pharmacology
- A novel therapy using phosphodiesterase(PDE) inhibitors for chronic inflammatory diseases
- Investigation of the regulatory mechanism of SIGIRR expression, a negative regulator of Toll like receptor signaling
Professor: Naofumi Tokutomi, PhD
Associate Professor: Yuji Uchida, MD, PhD
Assistant Professor: Keiko Shuto, PhD
Molecular Cell Pharmacology
- Development of peptidomimetic probes for tumor cell death
- Molecular function of nucleoporins in diseases
- Development of MRI-techniques in neurodegenerative diseases
Professor: Akihiko Kuniyasu, PhD
Associate Professor: Masaki Makise, PhD
Microbiology & Oncology
- Development of preventative and therapeutic agents for herpetic disease.
- Development of preventative and therapeutic agents for infectious nonbacterial gastroenteritis.
- Antitumor effect of micelles of zinc protoporphyrin congated to styrene maleic acid anhydride (SMA) copolymer.
- Combinational effect of antitumor drug and heme oxygenase-1(OH-1) inhibitor.
- Micelles of zinc protoporphyrin congated to N-(2-hydroxypropyl)methacrylamide(HPMA) copolymer for imaging and light-induced antitumor effect.
Professor: Kazumi Yokomizo, PhD
Associate Professor: Jun Fang, MD
Assistant Professor: Jian-Rong Zhou, PhD
Assistant Professor: Hideaki Nakamura, PhD
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- Oxidative stress on human health
- Evaluation of the toxicity of dihydropyrazine (DHP) derivatives
- Analysis of a role of the zinc transporter in oxidative stress
Professor: Shinji Takechi, PhD
Associate Professor: Takumi Ishida, PhD
Environmental Science & Technology
- Development of selenium-dependent glutathione peroxidase mimics
- Development of liposomal anti-cancer drug delivery systems
- Development of selenophene-based polymeric drug carrier
Professor: Mamoru Haratake, PhD
- Molecular structure analysis with X-ray crystallography and molecular modeling
- Estimation of diffusion coefficients based on experiments and molecular modeling
Professor: Shuichi Miyamoto, PhD
Assistant Professor: Akito Kawai, PhD
- Non-invasive measurement of redox state with ESR-spin probe technique and analysis of the relation of the redox state to pathological condition
- Development of multi-functional contrast agents for MRI/ESR imaging toward the fusion of diagnosis and therapy (theranostics)
- Application of MRI/ESR to analysis of pharmacokinetics
- Analysis of photo-induced radical reactions related to side effects of drugs
- Development of sensitive method to measure reactive oxygen species using chemiluminescence technique
Professor: Keizo Takeshita, Ph.D.
Senior Assistant Professor: Shoko Okazaki, Ph.D.
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- Mechanistic studies of new catalyses
- The chemistry of indium in its low-oxidation state
- Design and Synthesis of Novel Nucleotide Analogs as Anti HBV Agents
- Site Specific DNA/RNA Modification by Artificial Nucleobase
Associate Professor: Hisao Kansui, PhD
Associate Professor: Shuhei Imoto, PhD
- Synthetic design using multi-step sequential pericyclic reactions (cascade reactions)
- Computer assisted molecular design and simulation of pericyclic reactions 3. Isolation and structure analysis of atropisomers 4. Lattice-assistes inclusion compounds (clathrates)
Professor: Masashi Eto, PhD
Associate Professorr: Yasuyuki Yoshitake, PhD
Lecturer: Koki Yamaguchi, PhD
- Study on isoflavone glycosides from Fabaceae plants inhibit the cancer cell growth
- Evaluation of the immunosuppressive activity by using cycloartane glycosides in the Ranunculaceae plants
- Study on prenylated flavonoids from Epimedium herba inhibit the formation of advanced glycation end-products
- Effect of triterpenoids contained in Rosaceae plants on macrophage activation
Professor: Hitoshi Yoshimitsu, PhD
Professor: Tsuyoshi Ikeda, PhD
Lecturer: Hiroyuki Miyashita, PhD
Medical Plant Garden
- Cultivation of Lithospermum officinale var. erythrorhizon and Valeriana officinalis var. latifolia
- Constituent part of Pueraria lobata and Atractylodes japonica
Professor: Kotaro Murakami, Ph.D
Technical officer: Sachio Honnda
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