Publications:
- Esaki, M., Ishida, T., Miyauchi, Y., Takechi, S.:The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. J. Toxicol. Sci., 45, 401-409 (2020). DOI:10.2131/jts.45.401
- Ishida, T., Takechi, S.: β-Naphthoflavone , an exogenous ligand of aryl hydrocarbon receptor , disrupts zinc homeostasis in human hepatoma.J. Toxicol. Sci., 44, 1851-1858 (2019).
- Togawa, J., Ohi, T., Yuan, JH., Takashima, H., Furuya, H., Takechi, S., Fujitake, J., Hayashi, S., Ishiura, H., Naruse, H., Mitsui, J., Tsuji, S.: Atypical Familial Amyotrophic Lateral Sclerosis with Slowly Progressing Lower Extremities-predominant Late-onset Muscular Weakness and Atrophy. Internal Medicine, 58, 1851-1858 (2019).
- Song, Y., Fujimoto, K., Kurose, A., Ishida, T., Koga, T., Li, R., Takeda, T., Takechi, S., Yamada, H., Tanaka, Y., Ishii, Y.: Hepatic Expression of Selenium Binding Protein (SelenBP) in Female Mice and Its Inducibility by 2,3,7,8-Tetrachlorodibenzo-p-dioxin : Study with SelenBP1-Knockout Mice. Fukuoka Acta Medica, 110, 128-132 (2019).
- Ishida, T., Takechi, S.: Nrf2-ARE-Dependent Alterations in Zinc Transporter mRNA Expression in HepG2 Cells. PLoS One., 11, e0166100 (2016).
- Ishida, T., Yamaguchi, T., Takechi, S.: 3-Hydro-2,2,5,6-tetramethylpyrazine: a novel inducer of zinc transporter-1 in HepG2 human hepatocellular carcinoma cells. Arch. Biochem. Biophys., 580, 57-63 (2015).
- Takechi, S., Ito, S., Kashige, N., Ishida, T., Yamaguchi, T.: Identification of dihydropyrazine-glutathione adducts. J. Toxicol. Sci., 40, 495-500 (2015).
- Ishida, T., Yamaguchi, T.,Takechi, S.: The effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine. J. Toxicol. Sci., 39, 601-608 (2014).
- Tsujimoto, S., Ishida, T., Takeda, T., Ishii, Y., Onomura, Y., Tsukimori, K., Takechi, S., Yamaguchi, T., Uchi, H., Suzuki, SO., Yamamoto, M., Himeno, M., Furue. M., Yamada, H.: Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochim. Biophys. Acta, 1830, 3616-3624 (2013).
- Ishida, T., Takechi, S., Yamaguchi, T.: Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells. J. Toxicol. Sci., 37, 1065-1069 (2012).
- Koga,T., Ishida, T., Takeda, T., Ishii, Y., Uchi, H., Tsukimori, K., Yamamoto, M., Himeno, M., Furue, M., Yamada, H.: Restoration of Dioxin-Induced Damage to Fetal Steroidogenesis and Gonadotropin Formation by Maternal Co-Treatment with α-Lipoic Acid. PLoS One., 7, e40322 (2012).
- Yamaguchi, T., Matsumoto, S., Masumizu, T., Takechi, S., Ishida, T., Takeshita, K., Kansui, H., Kunieda, T.: Generation of radical species from dihydropyrazines having DNA strand-breakage activity and other characteristics. Chem. Pharm. Bull., 60, 639-646 (2012).
- Takechi, S., Ito, S., Kashige, N., Ishida, T. and Yamaguchi, T.: Glutathione Depression by dihydropyrazine derivative. J. Toxicol. Sci., 36, 231-235 (2011).
- Takeda, T., Yamamoto, M., Himeno, M., Takechi, S., Yamaguchi, T., Ishida, T., Ishii, Y. and Yamada, H.: 2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries. J. Toxicol. Sci., 36, 221-229 (2011).
- Takechi, S., Kashige, N., Ishida, T. and Yamaguchi, T.: The effects of tetraazaindene, derived from dihydropyrazine, to break DNA strands and inhibit bacterial growth. J. Basic Appl. Chem., 1, 1-7 (2011).
- Ito, S., Hirano, T., Sugimoto, A., Kagechika, H., Takechi, S., Yamaguchi, T.: Latent Enamine Functionality of 5-methyl-2,3-dihydropyrazines. Chem. Pharm. Bull., 58, 922-927 (2010).
- Ito, S., Takechi, S., Nakahara, K., Kashige, N., Yamaguchi, T.: Phenyl-Substituted Dihydropyrazines with DNA Strand-Breakage Activity. Chem. Pharm. Bull., 58, 825-828 (2010).
- Takechi, S., Nakahara, K., Yamaguchi, T.: Dihydropyrazine-induced Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase. Biol. Pharm. Bull., 33, 379-383 (2010).
- Ishida, T., Matsumoto, Y., Takeda, T., Koga, T., Ishii, Y., Yamada, H.: Distribution of 14C-2,3,7,8-tetrachlorodibenzo-p-dioxin to the brain and peripheral tissues of fetal rats and its comparison with adults. J. Toxicol. Sci., 35, 563-569 (2010).
- Matsumoto, Y., Ishida, T., Takeda, T., Koga, T., Fujii, M., Ishii, Y., Fujimura, Y., Miura, D., Wariishi, H., Yamada, H.: Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis. J. Toxicol. Sci., 35, 365-373 (2010).
- Nakahara, K., Takechi, S., Yamaguchi, K., Harano, K., Yamaguchi, T.: Tetraazaindenes Derived from Dihydropyrazines with DNA strand-breakage activity. Chem. Pharm. Bull., 57, 1371-1375 (2009).
- Nakahara, K., Yamaguchi, K., Yoshitake, Y., Yamaguchi, T., Harano, K.: Chemical Reactivity of Dihydropyrazine Derivatives. Cycloaddition Behavior toward Ketenes. Chem. Pharm. Bull., 57, 846-52 (2009).
- Takechi, S., Nakahara, K., Adachi, M., Yamaguchi, T.: Oxidative Stress Induced by a Dihydropyrazine Derivative. Biol. Pharm. Bull., 32, 186-89 (2009).
- Ishida, T., Takeda, T., Koga, T., Yahata, M., Ike, A., Kuramoto, C., Taketoh, J., Hashiguchi, I., Akamine, A., Ishii, Y., Yamada, H.: Attenuation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by resveratrol: a comparative study with different routes of administration. Biol. Pharm. Bull., 32, 876-881 (2009).
- Takeda, T., Matsumoto, Y., Koga, T., Mutoh, J., Nishimura, Y., Shimazoe, T., Ishii, Y., Ishida, T., Yamada, H.: Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior. J. Pharmacol. Exp. Ther., 329, 1091-1099 (2009).
- Ishida, T., Ishizaki, M., Tsutsumi, S., Ishii, Y., Yamada, H.: Piperine, a pepper ingredient, improves the hepatic increase in fatty acids caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Health Sci., 54, 551-558 (2008).
- Ishida, T., Kawakami, M., Baba, H., Yahata, M., Mutoh, J., Takeda, S., Fujita, H., Tanaka, Y., Ishii, Y., Yamada, H.: Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins. Environ. Toxicol. Pharmacol., 26, 348-354 (2008).
- Takeda, O., Takechi, S., Ito, S., Omori, H., Katoh, T. and Yamaguchi, T.: Effects of Phenyl Derivatives of Dihydropyrazines with Ability to Generate Radical Species on Escherichia coli. Biol. Pharm. Bull., 30, 1663―1667 (2007).
- Yamaguchi, T., Ito, S., Kashige, N., Nakahara, K. and Harano, K.: The Relationship between the Chemical Structures of Dihydropyrazine Derivatives and DNA Strand-Breakage Activity. Chem. Pharm. Bull., 55, 532-36 (2007).
- Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T., Yamada, H.: Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary. Life Sci., 80, 1259-1267 (2007).
- Takechi, S., Yamaguchi, T., Nomura, H., Minematsu, T., Adachi, M., Kurata, H. and Kurata, R.: Mutation spectrum induced by dihydropyrazines in Escherichia coli. Biol. Pharm. Bull., 29, 17-20 (2006).
- Mutoh, J., Taketoh, J., Okamura, K., Kagawa, T., Ishida, T., Ishii, Y., Yamada, H.: Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Endocrinology, 147, 927-936 (2006).
- Ishida, T., Nishimura, A., Mutoh, J.,? Yamada, H.: Enhancement of dioxin toxicity with anti-stress drug, carbenoxolone, in mice. J. Health Sci., 52, 30-35 (2006).
- Maruoka, H., Kashige, N., Miake, F. and Yamaguchi, T.: Synthesis of new dihydropyrazines with DNA strand-breakage activity. Chem. Pharm. Bull., 53, 1359-1361 (2005).
- Takeda, O., Takechi, S., Katoh, T. and Yamaguchi, T.: The role of dihydropyrazines in accelerated death of Escherichia coli on addition of Copper (II). Biol. Pharm. Bull., 28, 1161-1164 (2005).
- Kashige, N., Takeuchi, T., Matsumoto, S., Takechi, S., Miake, F. and Yamaguchi, T.: Radical species in DNA strand-cleavage caused by dihydropyrazines. Biol. Pharm. Bull., 28, 419-423 (2005).
- Ishida, T., Hori, M., Ishii, Y., Oguri, K., Yamada, H.: Effects of dioxins on stress-responsive systems and their relevance to toxicity. J. Dermatol. Sci., Suppl. 1, S105-S112 (2005).
- Ishida, T., Naito, E., Mutoh, J., Takeda, S., Ishii, Y., Yamada, H.: The plant flavonoid, quercetin, reduces some forms of dioxin toxicity by mechanism distinct from aryl hydrocarbon receptor activation, heat-shock protein induction and quenching oxidative stress. J. Health Sci., 51, 410-417 (2005).
- Ishida, T., Kan-o, S., Mutoh, J., Takeda, S., Ishii, Y., Hashiguchi, I., Akamine, A., Yamada, H.: 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportation. Toxicol. Appl. Pharmacol., 205, 89-97 (2005).
- Ohi, T., Nabeshima, K., Kato, S., Yazawa, S. and Takechi, S.: Familial amyotrophic lateral sclerosis with His46Arg mutation in Cu/Zn superoxide dismutase presenting characteristic clinical features and Lewy body-like hyaline inclusions, J. Neurol. Sci., 225, 19-25 (2004).
- Takechi, S., Yamaguchi, T., Nomura, H., Minematsu, T. and Nakayama, T.: Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity, Mutat. Res., 560, 49-55 (2004).
- Ishida, T., Oshimo, T., Nishimura, A., Mutoh, J., Ishii, Y., Koga, N., Yamada, H., Hashiguchi, I., Akamine, A., Oguri, K.: Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetone. Biol. Pharm. Bull., 27, 1397-1402 (2004).
- Ishida, T., Abe, M., Oguri, K., Yamada, H.: Enhancement of acetaminophen cytotoxicity in selenium-binding protein-overexpressed COS-1 cells. Drug Metab. Pharmacokinet., 19, 290-296 (2004).
- Ishida, T., Taketoh, J., Nakatsune, E., Kan-o, S., Naito, E., Takeda, S., Mutoh, J., Ishii, Y., Yamada, H.: Curcumin anticipates the suppressed body weight gain with 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice. J. Health Sci., 50, 474-482 (2004).
- Ito, S. and Yamaguchi, T.: The formation and the biological effects of dihydropyrazines derived from sugars: Tokyo Medical and Dental University, Reports of the Institute of Biomaterials and Bioengineering 37,16-23 (2003).
- Yamaguchi, T., Nomura, H., Matsunaga, K., Ito, S., Takata, J. and Karube, Y.: The Behavior of Dihydropyrazine with DNA Strand-Breakage Activity in Vivo, Biol.Pharm.Bull., 26, 1523-1527 (2003).
- Mibu, N., Yukawa, M., Kashige, N., Iwase, Y., Goto,Y., Miake, F., Yamaguchi, T., Ito, S. and Sumoto, K.: Synthesis and DNA Strand Breakage Activity fo Some 1,4-Diazepines, Chem.Pharm.Bull., 51, 27-31 (2003).
- Yamaguchi, T., Ito, S., Mibu, N. and Sumoto, K.: Reaction of 2,3-Butanedione with Propylenediamine Observed by 1H-NMR Spectroscopy, Heterocycles, 57, 11-16 (2002).
- Takechi, S., Adachi, M and Nakayama, T.: Chicken HDAC2 down-regulates IgM light chain gene promoter activity, Biochem. Biophys. Res. Commun., 299, 263-267 (2002).
- Takechi, S., Adachi, M and Nakayama, T.: Cloning and characterization of the chick Oct binding factor OBF-1, Biochim. Biophys. Acta, 1577, 466-470 (2002).
- Ohi, T., Saito, K., Takechi, S., Nabesima, K., Tashiro, H., Shiomi, K., Sugimoto, S., Akematsu, T., Nakayama, T., Iwaki, M. and Matsukura, S.: Clinical features and neuropathological findings of familial amyotrophic lateral sclerosis with a His46Arg mutation in Cu/Zn superoxide dismutase, J. Neurol. Sci., 197, 73-78 (2002).
- Ishida, T., Ishii, Y., Yamada, H., Oguri, K.: The induction of hepatic selenium-binding protein by aryl hydrocarbon (Ah)-receptor ligands in rats. J. Health Sci., 48, 62-68 (2002).
- Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Yamada, H., Oguri, K.: Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo. J. Health Sci., 47, 575-578 (2001).
- Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Yamada, H., Oguri, K.: Effects of a highly toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl on intermediary metabolism : Reduced triose phosphate content in rat liver cytosol. Fukuoka Acta Med., 92(5), 190-200 (2001).
- Kashige, N., Yamaguchi, T., Miake, F. and Watanabe, K.: Nucleotide Sequence Specificity in DNA Cleavage Caused by Dihydropyrazines, a New Type of DNA Strand-Cleaving Agent, Biol. Pharm. Bull., 23:1281-1286 (2000).
- Yamaguchi, T., Ito, S., Iwase, Y., Watanabe, K. and Harano, K.: A Diamine-Exchange Reaction of Dihydropyrazines, Heterocycles, 53, 1677-1680 (2000).
- Kashige, N., Yamaguchi, T., Miake, F. and Watanabe, K.: Nucleotide Sequence Specificity in DNA Cleavage Caused by Dihydropyrazines, a New Type of DNA Strand-Cleaving Agent, Biol. Pharm. Bull., 23, 1281-1286 (2000).
- Ohi, T., Takechi, S., Itokazu, N., Shiomi, K., Sugimoto, S., Antoku, Y., Kato, K., Sugimoto, T., Nakayama, T. and Matsukura, S.: Two novel mutations in the adrenoleukodystrophy gene in two unrelated Japanese families and the long-term effect of bone marrow transplantation, J. Neurol. Sci., 177, 131-138 (2000).
- Kawano, J., Kotani,T., Ogata, Y., Ohtaki,S., Takechi,S., Nakayama,T., Sawaguchi, A., Nagaike, R., Oinuma, T., and Suganuma, T.: CALNUC (nucleobindin) is localized in the Golgi apparatus in insect cells, Eur. J. Cell Biol., 79, 208-217 (2000).
- Ikeda, M., Ishii, Y., Kato, H., Akazawa, D., Hatsumura, M., Ishida, T., Matsusue, K., Yamada, H., Oguri, K.: Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. Arch. Biochem. Biophys., 380, 159-164 (2000).
- Yamaguchi, T., Eto, M., Harano, K., Kashige, N., Watanabe, K. and Ito, S.: New Compounds Derived from Dihydropyrazines Having DNA Strand-Breakage Activity, Tetrahedron, 55, 675-686 (1999).
- Hiraku, Y., Sugimoto, J., Yamaguchi, T. and Kawanishi, s.: Oxidative DNA Damage lnduced by Aminoacetone, an Amino Acid Metabolite, Archives of Biochemistry and Biophysics, 365, 62-70 (1999).
- Yamaguchi, T., Ito, S., Iwase, Y., Watanabe, K. and Harano, K.: Products from a Novel Reaction of Dihydropyrazines with Vichinaldiamines, Heterocycles, 51, 2305-2309 (1999).
- Takechi, S. and Nakayama, T.: Sas3 is a histone acetyltransferase and requires a zinc finger motif, Biochem. Biophys. Res. Commun., 266, 405-410 (1999).
- Ishida, T., Fukuda, A., Yoshioka, Y., Maji, D., Ishii Y., Oguri, K.: An improved method for the purification and characterization of a 54 kDa protein in rat liver which has recently been identified as a selenium-binding protein. J. Health Sci., 45, 203-208 (1999).
- Ishida, T., Tasaki, K., Fukuda, A., Ishii, Y., Oguri, K.: Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein. Environ. Toxicol. Pharmacol., 6, 249-255 (1999).
- Yamaguchi, T., Kashige, N., Matsumoto, S., Satoh, K., Yasuda, M. and Watanabe, K.: A Carbon-Centered Radical as a Reaction Species in the DNA Strand-Breakage by D-Glucosamine, Biol. Pharm. Bull., 21 (3), 205-209 (1998).
- Yamaguchi, T., Matsumoto, S. and Watanabe, K.: Generation of Free Radicals from Dihydropyrazines with DNA Strand-Breakage Activity, Tetrahedron Lett., 8311-8312 (1998).
- Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Oguri, K.: Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. Toxicology, 116, 193-199 (1997).
- Yamaguchi, T., Kashige, N., Mishiro, N., Miake, F. and Watanabe, K.: Dihydropyrazine Derivatives as a New Type of DNA Strand Breaking Agent, Biol. Pharm. Bull., 19, 1261-1265 (1996).
- Yamaguchi, T., Eto, M., Watanabe, K., Kashige, N. and Harano, K.: Formation of Tricyclic Heterocycles from the Condensation Reaction of 1.2-Diamines with 1.2-Diketones, Chem. Pharm. Bull., 44, 1977-1979 (1996).
- Yamaguchi, T., Uchimura, K., Mishiro, N. and Watanabe, K.: Evidence of Presence of Thiamin Diphosphate Kinase in Human Erythrocytes, Jpn. J. Toxicol. Environ. Health, 42, 524-528 (1996).
- Ogura, K., Takechi, S., Nakayama, T. and Yamamoto, M.: Molecular structure of the transposable element ninja in Drosophila simulans, Genes Genet. Syst., 71, 1-8 (1996).
- Takami, Y., Higashio, M., Fukuoka, T., Takechi, S. and Nakayama, T.: Organizatoin of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences, DNA Res., 3, 95-99 (1996).
- Ishii, Y., Hatsumura, M., Ishida, T., Ariyoshi, N., Oguri, K.: Significant induction of a 54 kDa protein in rat liver with homologous alignment to mouse selenium binding protein by a coplanar polychlorinated biphenyl, 3,4,5,3',4'-pentachlorobiphenyl and 3-methylcholanthrene. Toxicol. Lett., 87, 1-9 (1996).
- Ishii, Y., Hatsumura, M., Ishida, T., Ariyoshi, N., Oguri, K.: A coplanar PCB induces a selenium binding protein as a major cytosolic protein in rat liver. Chemosphere, 32 (3), 509-515 (1996).
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