• Ishida, T., Takechi, S.: Nrf2-ARE-Dependent Alterations in Zinc Transporter mRNA Expression in HepG2 Cells. PLoS One., 11, e0166100 (2016).

  • Ishida, T., Yamaguchi, T., Takechi, S.: 3-Hydro-2,2,5,6-tetramethylpyrazine: a novel inducer of zinc transporter-1 in HepG2 human hepatocellular carcinoma cells. Arch. Biochem. Biophys., 580, 57-63 (2015).
  • Takechi, S., Ito, S., Kashige, N., Ishida, T., Yamaguchi, T.: Identification of dihydropyrazine-glutathione adducts. J. Toxicol. Sci., 40, 495-500 (2015).

  • Ishida, T., Yamaguchi, T., Takechi, S.: The effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine. J. Toxicol. Sci., 39, 601-608 (2014).

  • Tsujimoto, S., Ishida, T., Takeda, T., Ishii, Y., Onomura, Y., Tsukimori, K., Takechi, S., Yamaguchi, T., Uchi, H., Suzuki, SO., Yamamoto, M., Himeno, M., Furue. M., Yamada, H.: Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochim. Biophys. Acta, 1830, 3616-3624 (2013).

  • Ishida, T., Takechi, S., Yamaguchi, T.: Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells. J. Toxicol. Sci., 37, 1065-1069 (2012).
  • Koga,T., Ishida, T., Takeda, T., Ishii, Y., Uchi, H., Tsukimori, K., Yamamoto, M., Himeno, M., Furue, M., Yamada, H.: Restoration of Dioxin-Induced Damage to Fetal Steroidogenesis and Gonadotropin Formation by Maternal Co-Treatment with α-Lipoic Acid. PLoS One., 7, e40322 (2012).
  • Yamaguchi, T., Matsumoto, S., Masumizu, T., Takechi, S., Ishida, T., Takeshita, K., Kansui, H., Kunieda, T.: Generation of radical species from dihydropyrazines having DNA strand-breakage activity and other characteristics. Chem. Pharm. Bull., 60, 639-646 (2012).

  • Takechi, S., Ito, S., Kashige, N., Ishida, T. and Yamaguchi, T.: Glutathione Depression by dihydropyrazine derivative. J. Toxicol. Sci., 36, 231-235 (2011).[ jstage ]
  • Takeda, T., Yamamoto, M., Himeno, M., Takechi, S., Yamaguchi, T., Ishida, T., Ishii, Y. and Yamada, H.: 2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries. J. Toxicol. Sci., 36, 221-229 (2011).[ jstage ]
  • Takechi, S., Kashige, N., Ishida, T. and Yamaguchi, T.: The effects of tetraazaindene, derived from dihydropyrazine, to break DNA strands and inhibit bacterial growth. J. Basic Appl. Chem., 1, 1-7 (2011).

  • Ito, S., Hirano, T., Sugimoto, A., Kagechika, H., Takechi, S., Yamaguchi, T.: Latent Enamine Functionality of 5-methyl-2,3-dihydropyrazines. Chem. Pharm. Bull., 58, 922-927 (2010).[ jstage ] Selected as a journal cover of issue 7.
  • Ito, S., Takechi, S., Nakahara, K., Kashige, N., Yamaguchi, T.: Phenyl-Substituted Dihydropyrazines with DNA Strand-Breakage Activity. Chem. Pharm. Bull., 58, 825-828 (2010).[ jstage ]
  • Takechi, S., Nakahara, K., Yamaguchi, T.: Dihydropyrazine-induced Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase. Biol. Pharm. Bull., 33, 379-383 (2010).[ jstage ]
  • Ishida, T., Matsumoto, Y., Takeda, T., Koga, T., Ishii, Y., Yamada, H.: Distribution of 14C-2,3,7,8-tetrachlorodibenzo-p-dioxin to the brain and peripheral tissues of fetal rats and its comparison with adults. J. Toxicol. Sci., 35, 563-569 (2010).
  • Matsumoto, Y., Ishida, T., Takeda, T., Koga, T., Fujii, M., Ishii, Y., Fujimura, Y., Miura, D., Wariishi, H., Yamada, H.: Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis. J. Toxicol. Sci., 35, 365-373 (2010).

  • Nakahara, K., Takechi, S., Yamaguchi, K., Harano, K., Yamaguchi, T.: Tetraazaindenes Derived from Dihydropyrazines with DNA strand-breakage activity. Chem. Pharm. Bull., 57, 1371-1375 (2009).[ cpb ]
  • Nakahara, K., Yamaguchi, K., Yoshitake, Y., Yamaguchi, T., Harano, K.: Chemical Reactivity of Dihydropyrazine Derivatives. Cycloaddition Behavior toward Ketenes. Chem. Pharm. Bull., 57, 846-52 (2009).[ cpb ]
  • Takechi, S., Nakahara, K., Adachi, M., Yamaguchi, T.: Oxidative Stress Induced by a Dihydropyrazine Derivative. Biol. Pharm. Bull., 32, 186-89 (2009).[ jstage ]
  • Ishida, T., Takeda, T., Koga, T., Yahata, M., Ike, A., Kuramoto, C., Taketoh, J., Hashiguchi, I., Akamine, A., Ishii, Y., Yamada, H.: Attenuation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by resveratrol: a comparative study with different routes of administration. Biol. Pharm. Bull., 32, 876-881 (2009).
  • Takeda, T., Matsumoto, Y., Koga, T., Mutoh, J., Nishimura, Y., Shimazoe, T., Ishii, Y., Ishida, T., Yamada, H.: Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior. J. Pharmacol. Exp. Ther., 329, 1091-1099 (2009).
  • 石田卓巳, 坂井雄一, 石井祐次, 古江増隆, 山田英之, Cholebine による 2,3,4,7,8-pentachlorodibenzofuran 排泄促進. 福岡医学雑誌, 100, 210-216 (2009).

  • Ishida, T., Ishizaki, M., Tsutsumi, S., Ishii, Y., Yamada, H.: Piperine, a pepper ingredient, improves the hepatic increase in fatty acids caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Health Sci., 54, 551-558 (2008). Journal of Health Science Best Paper Award 2008.
  • Ishida, T., Kawakami, M., Baba, H., Yahata, M., Mutoh, J., Takeda, S., Fujita, H., Tanaka, Y., Ishii, Y., Yamada, H.: Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins. Environ. Toxicol. Pharmacol., 26, 348-354 (2008).

  • Takeda, O., Takechi, S., Ito, S., Omori, H., Katoh, T., Yamaguchi, T.: Effects of Phenyl Derivatives of Dihydropyrazines with Ability to Generate Radical Species on Escherichia coli. Biol. Pharm. Bull., 30, 1663―1667 (2007). [ CiNii ]
  • Yamaguchi, T., Ito, S., Kashige, N., Nakahara, K. and Harano, K.: The Relationship between the Chemical Structures of Dihydropyrazine Derivatives and DNA Strand-Breakage Activity. Chem. Pharm. Bull., 55, 532-36 (2007). [ CiNii ]
  • Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T., Yamada, H.: Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary. Life Sci., 80, 1259-1267 (2007).
  • 武藤純平, 石田卓巳, 石井祐次, 山田英之, ダイオキシン類母体暴露がマウス胎仔精巣の性ステロイドホルモン生合成系発現に及ぼす影響. 福岡医学雑誌, 98, 203-207 (2007).

  • Takechi, S., Yamaguchi, T., Nomura, H., Minematsu, T., Adachi, M., Kurata, H. and Kurata, R.: Mutation spectrum induced by dihydropyrazines in Escherichia coli. Biol. Pharm. Bull., 29, 17-20 (2006). [ CiNii ]
  • Mutoh, J., Taketoh, J., Okamura, K., Kagawa, T., Ishida, T., Ishii, Y., Yamada, H.: Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Endocrinology, 147, 927-936 (2006).
  • Ishida, T., Nishimura, A., Mutoh, J.,? Yamada, H.: Enhancement of dioxin toxicity with anti-stress drug, carbenoxolone, in mice. J. Health Sci., 52, 30-35 (2006).

  • Miyata, T., Kashige, N., Satho, T., Yamaguchi, T., Aso, Y., Miake, F.: Cloning, Sequence Analysis, and Expression of the Gene Encoding Sphingomonas paucimobilis FP2001 945-L-RhamnosidaseAutores. Current Microbiology An International Journal, 51, 105-109 (2005)
  • Maruoka, H., Kashige, N., Miake, F. and Yamaguchi, T.: Synthesis of newdihydropyrazines with DNA strand-breakage activity. Chem. Pharm. Bull., 53, 1359-1361 (2005). [ CiNii ]
  • Takeda, O., Takechi, S., Katoh, T. and Yamaguchi, T.: The role of dihydropyrazines in accelerated death of Escherichia coli on addition of Copper (II). Biol. Pharm. Bull., 28, 1161-1164 (2005). [ CiNii ]
  • Kashige, N., Takeuchi, T., Matsumoto, S., Takechi, S., Miake, F. and Yamaguchi, T.: Radical species in DNA strand-cleavage caused by dihydropyrazines. Biol. Pharm. Bull., 28, 419-423 (2005). [ CiNii ]
  • Ishida, T., Hori, M., Ishii, Y., Oguri, K., Yamada, H.: Effects of dioxins on stress-responsive systems and their relevance to toxicity. J. Dermatol. Sci., Suppl. 1, S105-S112 (2005).
  • Ishida, T., Naito, E., Mutoh, J., Takeda, S., Ishii, Y., Yamada, H.: The plant flavonoid, quercetin, reduces some forms of dioxin toxicity by mechanism distinct from aryl hydrocarbon receptor activation, heat-shock protein induction and quenching oxidative stress. J. Health Sci., 51, 410-417 (2005).
  • Ishida, T., Kan-o, S., Mutoh, J., Takeda, S., Ishii, Y., Hashiguchi, I., Akamine, A., Yamada, H.: 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportation. Toxicol. Appl. Pharmacol., 205, 89-97 (2005).
  • 石井祐次, 石田卓巳, 武藤純平, 山田英之, 小栗一太, ダイオキシン類の毒性を安全に軽減できる化合物の候補:油症治療を目指した検討. 福岡医学雑誌, 96, 204-213 (2005).

  • Ohi, T., Nabeshima, K., Kato, S., Yazawa, S. and Takechi, S.: Familial amyotrophic lateral sclerosis with His46Arg mutation in Cu/Zn superoxide dismutase presenting characteristic clinical features and Lewy body-like hyaline inclusions, J. Neurol. Sci., 225, 19-25 (2004)
  • Takechi, S., Yamaguchi, T., Nomura, H., Minematsu, T. and Nakayama, T.: Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity, Mutat. Res., 560, 49-55 (2004)
  • Ishida, T., Oshimo, T., Nishimura, A., Mutoh, J., Ishii, Y., Koga, N., Yamada, H., Hashiguchi, I., Akamine, A., Oguri, K.: Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetone. Biol. Pharm. Bull., 27, 1397-1402 (2004).
  • Ishida, T., Abe, M., Oguri, K., Yamada, H.: Enhancement of acetaminophen cytotoxicity in selenium-binding protein-overexpressed COS-1 cells. Drug Metab. Pharmacokinet., 19, 290-296 (2004).
  • Ishida, T., Taketoh, J., Nakatsune, E., Kan-o, S., Naito, E., Takeda, S., Mutoh, J., Ishii, Y., Yamada, H.: Curcumin anticipates the suppressed body weight gain with 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice. J. Health Sci., 50, 474-482 (2004).

  • Ito, S. and Yamaguchi, T.: The formation and the biological effects of dihydropyrazines derived from sugars: Tokyo Medical and Dental University, Reports of the Institute of Biomaterials and Bioengineering 37,16-23 (2003)
  • Yamaguchi, T., Nomura, H., Matsunaga, K., Ito, S., Takata, J. and Karube, Y.: The Behavior of Dihydropyrazine with DNA Strand-Breakage Activity in Vivo, Biol.Pharm.Bull., 26, 1523-1527 (2003)
  • Mibu, N., Yukawa, M., Kashige, N., Iwase, Y., Goto,Y., Miake, F., Yamaguchi, T., Ito, S. and Sumoto, K.: Synthesis and DNA Strand Breakage Activity of Some 1,4-Diazepines, Chem.Pharm.Bull., 51, 27-31 (2003)
  • 石田卓巳, 益崎泰宏, 西村嘉雄, 山田英之, ダイオキシン類の生殖毒性と後世代への影響並びにその機構. 福岡医学雑誌, 94, 183-195 (2003).

  • Yamaguchi, T., Ito, S., Mibu, N. and Sumoto, K.: Reaction of 2,3-Butanedione with Propylenediamine Observed by 1H-NMR Spectroscopy, Heterocycles, 57, 11-16 (2002)
  • Takechi, S., Adachi, M and Nakayama, T.: Chicken HDAC2 down-regulates IgM light chain gene promoter activity, Biochem. Biophys. Res. Commun., 299, 263-267 (2002)
  • Takechi, S., Adachi, M and Nakayama, T.: Cloning and characterization of the chick Oct binding factor OBF-1, Biochim. Biophys. Acta, 1577, 466-470 (2002)
  • Ohi, T., Saito, K., Takechi, S., Nabesima, K., Tashiro, H., Shiomi, K., Sugimoto, S., Akematsu, T., Nakayama, T., Iwaki, M. and Matsukura, S.: Clinical features and neuropathological findings of familial amyotrophic lateral sclerosis with a His46Arg mutation in Cu/Zn superoxide dismutase, J. Neurol. Sci., 197, 73-78 (2002)
  • Ishida, T., Ishii, Y., Yamada, H., Oguri, K.: The induction of hepatic selenium-binding protein by aryl hydrocarbon (Ah)-receptor ligands in rats. J. Health Sci., 48, 62-68 (2002).

  • Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Yamada, H., Oguri, K.: Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo. J. Health Sci., 47, 575-578 (2001).
  • Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Yamada, H., Oguri, K.: Effects of a highly toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl on intermediary metabolism : Reduced triose phosphate content in rat liver cytosol. Fukuoka Acta Med., 92(5), 190-200 (2001).
  • 吉岡優子, 石井祐次, 石田卓巳, 山田英之, 小栗一太, 本島清人, コプラナー PCB による小胞体局在ストレス蛋白質の発現制御に関する研究 ?第2報?. 福岡医学雑誌, 92, 201-216 (2001).

  • Kashige, N., Yamaguchi, T., Miake, F. and Watanabe, K.: Nucleotide Sequence Specificity in DNA Cleavage Caused by Dihydropyrazines, a New Type of DNA Strand-Cleaving Agent, Biol. Pharm. Bull., 23:1281-1286 (2000)
  • Yamaguchi, T., Ito, S., Iwase, Y., Watanabe, K. and Harano, K.: A Diamine-Exchange Reaction of Dihydropyrazines, Heterocycles, 53, 1677-1680 (2000)
  • Kashige, N., Yamaguchi, T., Miake, F. and Watanabe, K.: Nucleotide Sequence Specificity in DNA Cleavage Caused by Dihydropyrazines, a New Type of DNA Strand-Cleaving Agent, Biol. Pharm. Bull., 23, 1281-1286 (2000)
  • Ohi, T., Takechi, S., Itokazu, N., Shiomi, K., Sugimoto, S., Antoku, Y., Kato, K., Sugimoto, T., Nakayama, T. and Matsukura, S.: Two novel mutations in the adrenoleukodystrophy gene in two unrelated Japanese families and the long-term effect of bone marrow transplantation, J. Neurol. Sci., 177, 131-138 (2000)
  • Kawano, J., Kotani,T., Ogata, Y., Ohtaki,S., Takechi,S., Nakayama,T., Sawaguchi, A., Nagaike, R., Oinuma, T., and Suganuma, T.: CALNUC (nucleobindin) is localized in the Golgi apparatus in insect cells, Eur. J. Cell Biol., 79, 208-217 (2000)
  • Ikeda, M., Ishii, Y., Kato, H., Akazawa, D., Hatsumura, M., Ishida, T., Matsusue, K., Yamada, H., Oguri, K.: Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. Arch. Biochem. Biophys., 380, 159-164 (2000).

  • Yamaguchi, T., Eto, M., Harano, K., Kashige, N., Watanabe, K. and Ito, S.: New Compounds Derived from Dihydropyrazines Having DNA Strand-Breakage Activity, Tetrahedron, 55, 675-686 (1999)
  • Hiraku, Y., Sugimoto, J., Yamaguchi, T. and Kawanishi, s.: Oxidative DNA Damage lnduced by Aminoacetone, an Amino Acid Metabolite, Archives of Biochemistry and Biophysics, 365, 62-70 (1999)
  • Yamaguchi, T., Ito, S., Iwase, Y., Watanabe, K. and Harano, K.: Products from a Novel Reaction of Dihydropyrazines with Vichinaldiamines, Heterocycles, 51, 2305-2309 (1999)
  • Takechi, S. and Nakayama, T.: Sas3 is a histone acetyltransferase and requires a zinc finger motif, Biochem. Biophys. Res. Commun., 266, 405-410 (1999)
  • Ishida, T., Fukuda, A., Yoshioka, Y., Maji, D., Ishii Y., Oguri, K.: An improved method for the purification and characterization of a 54 kDa protein in rat liver which has recently been identified as a selenium-binding protein. J. Health Sci., 45, 203-208 (1999).
  • Ishida, T., Tasaki, K., Fukuda, A., Ishii, Y., Oguri, K.: Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein. Environ. Toxicol. Pharmacol., 6, 249-255 (1999).
  • 福田亜弥子, 石井祐次, 田崎健二, 松末公彦, 石田卓巳, 小栗一太, 高毒性コプラナー PCB によるラット肝分子シャペロン HSP70 および HSP90 の誘導. 福岡医誌, 90, 251-258 (1999).
  • 田崎健二, 石井祐次, 石田卓巳, 小栗一太, コプラナー PCB による小胞体局在性ストレスタンパク質の発現抑制. 福岡医誌, 90, 259-271 (1999).

  • Yamaguchi, T., Kashige, N., Matsumoto, S., Satoh, K., Yasuda, M. and Watanabe, K.: A Carbon-Centered Radical as a Reaction Species in the DNA Strand-Breakage by D-Glucosamine, Biol. Pharm. Bull., 21 (3), 205-209 (1998)
  • Yamaguchi, T., Matsumoto, S. and Watanabe, K.: Generation of Free Radicals from Dihydropyrazines with DNA Strand-Breakage Activity, Tetrahedron Lett., 8311-8312 (1998)

  • Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Oguri, K.: Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. Toxicology, 116, 193-199 (1997).
  • 石田卓巳, 石井祐次, 田崎健二, 有吉範高, 小栗一太 ラット肝サイトソル 54 kDa タンパク質に対する特異的抗体の産生 ?Coplanar PCBによる著しい誘導の検証?.? 福岡医誌, 88, 3-11 (1997).

  • 山口忠敏 : 血中セレン濃度と Duchenne 型筋ジストロフィー症, 日本臨牀 54, 134-140 (1996)
  • Yamaguchi, T., Kashige, N., Mishiro, N., Miake, F. and Watanabe, K.: Dihydropyrazine Derivatives as a New Type of DNA Strand Breaking Agent, Biol. Pharm. Bull., 19, 1261-1265 (1996)
  • Yamaguchi, T., Eto, M., Watanabe, K., Kashige, N. and Harano, K.: Formation of Tricyclic Heterocycles from the Condensation Reaction of 1.2-Diamines with 1.2-Diketones, Chem. Pharm. Bull., 44, 1977-1979 (1996)
  • Yamaguchi, T., Uchimura, K., Mishiro, N. and Watanabe, K.: Evidence of Presence of Thiamin Diphosphate Kinase in Human Erythrocytes, Jpn. J. Toxicol. Environ. Health, 42, 524-528 (1996)
  • Ogura, K., Takechi, S., Nakayama, T. and Yamamoto, M.: Molecular structure of the transposable element ninja in Drosophila simulans, Genes Genet. Syst., 71, 1-8 (1996)
  • Takami, Y., Higashio, M., Fukuoka, T., Takechi, S. and Nakayama, T.: Organizatoin of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences, DNA Res., 3, 95-99 (1996)
  • Ishii, Y., Hatsumura, M., Ishida, T., Ariyoshi, N., Oguri, K.: Significant induction of a 54 kDa protein in rat liver with homologous alignment to mouse selenium binding protein by a coplanar polychlorinated biphenyl, 3,4,5,3',4'-pentachlorobiphenyl and 3-methylcholanthrene. Toxicol. Lett., 87, 1-9 (1996).
  • Ishii, Y., Hatsumura, M., Ishida, T., Ariyoshi, N., Oguri, K.: A coplanar PCB induces a selenium binding protein as a major cytosolic protein in rat liver. Chemosphere, 32 (3), 509-515 (1996).