Akito KAWAI, Ph.D.

Affiliation

Laboratory of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Sojo University

address:

 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan

contact:
 

Condensed biography

  • TEACHING/RESEARCH EXPERIENCE
  • 2014-  , Assistant Professor (Sojo University)
  • 2006-2014, Junior Lecturer (Sojo University)
  • EDUCATION
  • 2013, Ph.D. (Kumamoto University)
  • 2006, M.Pharm. (Kumamoto University)
  • 2004, B.Pharm. (Kumamoto University)

Research

Structural analysis of the protein complex involved in the 3R(DNA replication, repair, recombination) in Sulfolobus tokodaii.

1. Structural determination of PCNA2-PCNA3 complex using X-ray crystallographic analysis and small-angle X-ray scattering.

Publication

<research>

  • "Crystallographic analysis of the Ternary Complex of Octanoate and N-acetyl-L-methionine with Human Serum Albumin Reveals the Mode of their Stabilizing Interactions"
  • Kawai A., Chuang T.G.V., Kouno Y., Yamasaki K., Miyamoto S., Anraku M. and Otagiri M.
  • BBA - Proteins and Proteomics, 1865, 979-984 (2017) [PubMed]
  • "Crystal structure of family 4 uracil-DNA glycosylase from Sulfolobus tokodaii and a function of tyrosine 170 in DNA binding"
  • Kawai A., Higuchi S., Tsunoda M., Nakamura K.T., Yamagata Y. and Miyamoto S.
  • FEBS Lett., 589, 2675-2682 (2015) [PubMed]
  • "Purification, crystallization and preliminary X-ray analysis of uracil-DNA glycosylase from Sulfolobus tokodaii strain 7"
  • Kawai A., Higuchi S., Tsunoda M., Nakamura K.T., and Miyamoto S.
  • Acta Crystallogr. sect. F Struct. Biol. Cryst. Commun., 68, 1102-1105 (2012) [IUCr] [PubMed]
  • "A novel heterotetrameric structure of the crenarchaeal PCNA2-PCNA3 complex"
  • Kawai A., Hashimoto H., Higuchi S., Tsunoda M., Sato M., Nakamura K.T., and Miyamoto S.
  • J. Struct. Biol., 174, 443-450 (2011) [PubMed]
  • "Purification, crystallization and preliminary X-ray analysis of the PCNA2-PCNA3 complex from Sulfolobus tokodaii strain 7"
  • Kawai A., Higuchi S., Tsunoda M., Nakamura K.T., and Miyamoto S.
  • Acta Crystallogr. sect. F Struct. Biol. Cryst. Commun., 65, 1282-1284 (2009) [IUCr] [PubMed]

<review and research collaboration>

  • "Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin"
  • Yamasaki K., Enokida T., Taguchi K., Miyamura S., Kawai A., Miyamoto S., Maruyama T., Seo H. and Otagiri M.
  • J. Pharm. Sci., 106, 2860-2867 (2017) [PubMed]
  • "Structural studies of coenzyme Q10 inclusion complex with γ-cyclodextrin using chemical analyses and molecular modeling"
  • Miyamoto S., Kawai A., Higuchi S., Nishi Y., Tanimoto T., Uekaji Y., Nakata D., Fukumi H., and Terao K.
  • Chem-Bio Infomatics Journal, 9, 1-11 (2009) [JST]

Biophysical Chemistry