* Molecular structure analysis with X-ray crystallography and molecular modeling

 (1) Structural analysis of PCNA from Sulfolobus tokodaii


* Structural study of peptides and proteins from venomous animals with special references to their biological activities

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Professor Shuichi MIYAMOTO
Professor Kazumi SHIMONO
Assistant Professor Akito KAWAI

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2017

  • "Crystallographic analysis of the Ternary Complex of Octanoate and N-acetyl-L-methionine with Human Serum Albumin Reveals the Mode of their Stabilizing Interactions"
  • Kawai A., Chuang T.G.V., Kouno Y., Yamasaki K., Miyamoto S., Anraku M. and Otagiri M.
  • BBA - Proteins and Proteomics, 1865, 979-984 [PubMed]
  • "Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin"
  • Yamasaki K., Enokida T., Taguchi K., Miyamura S., Kawai A., Miyamoto S., Maruyama T., Seo H. and Otagiri M.
  • J. Pharm. Sci., 106, 2860-2867 [PubMed]

2015

  • "Crystal structure of family 4 uracil-DNA glycosylase from Sulfolobus tokodaii and a function of tyrosine 170 in DNA binding"
  • A. Kawai, S. Higuchi, M. Tsunoda, K. T. Nakamura, Y. Yamagata and S. Miyamoto
  • FEBS Lett., 589, 2675-2682 [PubMed]

2012

  • "Purification, crystallization and preliminary X-ray analysis of uracil-DNA glycosylase from Sulfolobus tokodaii strain 7"
  • A. Kawai, S. Higuchi, M. Tsunoda, K. T. Nakamura, and S. Miyamoto
  • Acta Crystallogr. sect. F Struct. Biol. Cryst. Commun., 68, 1102-1105 [IUCr] [PubMed]

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2011

  • "A novel heterotetrameric structure of the crenarchaeal PCNA2-PCNA3 complex"
  • A. Kawai, H. Hashimoto, S. Higuchi, M. Tsunoda, M. Sato, K. T. Nakamura, and S. Miyamoto
  • J. Struct. Biol., 174, 443-450    [PubMed]

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2009

  • "Purification, crystallization and preliminary X-ray analysis of the PCNA2-PCNA3 complex from Sulfolobus tokodaii strain 7"
  • A. Kawai, S. Higuchi, M. Tsunoda, K. T. Nakamura, and S. Miyamoto
  • Acta Crystallogr. sect. F Struct. Biol. Cryst. Commun.,F65, 1282-1284    [IUCr] [PubMed]
  • "Structural studies of coenzyme Q10 inclusion complex with γ-cyclodextrin using chemical analyses and molecular modeling"
  • Miyamoto S., Kawai A., Higuchi S., Nishi Y., Tanimoto T., Uekaji Y., Nakata D., Fukumi H., and Terao K.
  • Chem-Bio Infomatics Journal, 2, 74-85    [JST]

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2006

  • "A novel peptide from the ACEI/BPP-CNP precursor in the venom of Crotalus durissus collilineatus"
  • Higuchi S., Murayama N., Saguchi K., Ohi H., Fujita Y., da Silva N.J. Jr, de Siqueira R.J., Lahlou S., Aird S.D.
  • Comp. Biochem. Physiol. C , 144 ,107-121    [PubMed]
  • "Molecular cloning of the major lethal toxins from two kraits (Bungarus flaviceps and Bungarus candidus)"
  • Yanoshita R., Ogawa Y., Murayama N., Omori-Satoh T., Saguchi K., Higuchi S., Khow O., Chanhome L., Samejima Y., Sitprija V.
  • Toxicon, 47 ,416-424  [PubMed]

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Biophysical Chemistry