Direct potentiation of capsaicin current by histamine and its effect by suplatast on rat trigeminal ganglia neurons Jian-Rong Zhou Tetsuya Shirasaki Fumio Soeda Kazumi Yokomizo Kazuo Takahama Pharmacology. Vol.102(1-2), pp.37-41. 201830 In this study, we investigated the effect of histamine on capsaicin-induced current and its influence by suplatast in rat trigeminal ganglia neurons using a patch-clamp technique. We found that histamine directly potentiated capsaicin- induced currents in rat sensory neurons, and suplatast had little effect on this potentiation. Since it has been known that suplatast suppresses histamine release from mast cells, it is possible that suplatast inhibits the activation of nociceptive fibers in the pathological condition via prevention of histamine-induced potentiation of the transient receptor potential vanilloid 1 (TRPV1) receptor- mediated currents. Tomato juice saponin, esculeoside B ameliorates mice experimental dermatitis Jian-Rong Zhou Jun Urata Takuya Shiraishi Chiaki Tanaka Toshihiro Nohara Kazumi Yokomizo Functional Foods in Health and Disease. Vol.8(4), pp.228-241. 201830 Background: Allergic diseases like atopic dermatitis have recently increased. A
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