cytotoxic activity against Vero cells. Among the tested compounds, C2-symmetrical bivalent meta-oriented phenylboronic acid 2f (n=7) showed high cytotoxic activity (CC50)=5.43 μM) against Vero cells. The results of an SAR study suggested that the presence of a C7-methylene linker group in the molecule is an important structural factor for expression of potential cytotoxic activities. A sugar recognition property of this C2-symmetrical geometric molecule was suggested by NMR analysis of compound 2f with methyl -D-glucopyranoside 6. Preparation and antiviral activity of some new C3- and CS-symmetrical tri-substituted triazine derivatives having benzylamine substituents Nobuko Mibu Kazumi Yokomizo Marina Sano Yuuna Kawaguchi Kenta Morimoto Syunsuke Shimomura Ryo Sato Nozomi Hiraga Aya Matsunaga Jian-Rong Zhou Tomonori Ohata Hatsumi Aki Kunihiro Sumoto Chem Pharm Bull. Vol.66(8), pp.830-838. 201830 We report the preparation of new C3- and CS-symmetrical molecules constructed on a triazine (TAZ) template. Anti-herpes simplex virus type 1 (anti-HSV-1) and cytotoxic activities against Vero cells of synthesized TAZ derivatives were evaluated. The results suggested that the presence of an electron-donating group(s) on the benzene ring in benzylamine groups on the TAZ template is an important structural factor for expressing a high level of anti-HSV-1 activity and low cytotoxicity for these C3 types of TAZ derivatives. Among the tested TAZ derivatives, compounds 4f and 7h showed the highest anti HSV-1 activities (EC50_0.98 and 1.23 μM, respectively) and low cytotoxic activities to Vero cells (50% cytotoxic concentration (CC50)_292.2 and >200 μM, respectively).
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