https://doi.org/10.1007/s10973-018-7573-4 201830 In our search for new bioactive compounds that interfere with the sugar recognition process, we have designed and synthesized C3- and Cs-symmetrical tripodal receptor-type molecules. Among the synthesized C3-symmetrical 2,4,6-trisubstituted 1,3,5-triazine (TAZ) derivatives, compounds A [2,4,6-tris(2-propoxy)-TAZ] and B [2,4,6-tris(3,4-dimethoxyphenyl)-TAZ] showed high levels of anti-HSV-1 activity. We carried out isothermal titration calorimetry on compound B·HCl in aqueous 25% 2-PrOH solution with some sugar derivatives including methyl α/β-D-galactopyranoside (MeO-α/β-Gal), methyl α/β-D-mannopyranoside (MeO-α/β-Man) and methyl α/β-D-glucopyranoside (MeO-α/β-Glc). The reactions of compound B·HCl with MeO-β-Gal and MeO-α-Man were exothermic, and the obtained thermodynamic profiles indicated that both reactions are spontaneous and that there is a considerably large enthalpic contribution (ΔH) in total Gibbs free energy change (ΔG), indicating favorable hydrogen bonding interactions. The reaction of compound B·HCl showed a thermodynamic signature different from that of the entropically driven reaction of compound A. Preparation of novel bivalent linker mode phenylboronic acid derivative and their biological evaluatin Makoto Furutachi Ayaka Matsumoto Tetsuya Tamenaga Aya Sugita Misato Kuroiwa, Kazumi Yokomizo Jian-Rong Zhou Nobuhiro Kashige Fumio Miake Kunihiro Sumoto Heterocycles. Vol.96(6), pp.1088-1100. 201830 We report a new route to the preparation of C2-symmetrical bivalent phenylboronic acids having alkyl linker groups in the molecule and results of biological evaluation of their biological activity and
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