崇城大学DDS研究所紀要第2巻2018年
34/61

Simple formula for predicting drug removal rates during hemodialysis Urata M Narita Y Fukunaga M Kadowaki D Hirata S Ther Apher Dial., Vol. 22(5),pp,485-493 201830 DDOI: 10.1111/1744-9987.12675. The present study sought to derive a simple formula for predicting the drug removal rates during hemodialysis. We examined the relationship between drug removal rates during hemodialysis and the molecular weights or pharmacokinetic parameters of injectable drugs (N = 90) obtained from pharmaceutical interview forms in Japan. Stepwise multiple regression analysis with the removal rate by hemodialysis as the objective variable adjusted for molecular weight or pharmacokinetic parameters as explanatory variables, showed that the logarithm of molecular weight (B = -18.87), the protein binding rate (B = -0.40), and the fraction of the unchanged drug excreted into the urine/volume of distribution (B = 0.05) were significantly and independently associated with drug removal rate by hemodialysis (α = 90.78, adjusted R2  = 0.64, P = 2.2e-16 ). Our data demonstrated that molecular weight, protein binding rate, and volume of distribution were important factors affecting drug removal during hemodialysis, and that our simple regression equation could be used to predict the drug removal rate during hemodialysis. Benzbromarone attenuates oxidative stress in angiotensin II- and salt-induced hypertensive model rats Muraya N Kadowaki D Miyamura S Kitamura K

元のページ  ../index.html#34

このブックを見る