C. Takei Y. OhtaniK. Kawashima A. Yoshida Y. Kojima Y. Egawa T. Seki D. Iohara M. Anraku F. Hirayama K. Uekama Mol. Pharmaceutics, Vol.15, pp.1097–1104 201830 DDOI: 10.1021/acs.molpharmaceut.7b00988A novel glucose (Glc)-responsive gel formed by worm-like micelles (WLMs) has the potential to provide a self-regulating insulin delivery system. We have prepared a WLM gel system using 75 mM cetyltrimethylammonium bromide, 75 mM phenylboronic acid, and water. The developed WLMs altered drug release rate, depending on Glc concentration. ( ) Displacement of protizinic acid by ibuprofen Nishi K Yamasaki K Otagiri M Acta Chim Pharm Indica, Vol. 7(3), pp.115-13 201729 The binding of protizinic acid [(10-methyl-7-methoxy-2- phenoxythiazinyl)-2-propionic acid, PA], a non-steroidal anti-inflammatory drug, to human serum albumin (HSA) was studied by dialysis and spectroscopic methods. A scatchard analysis of equilibrium dialysis (ED) data and the results of site marker displacement experiments suggest that PA predominantly binds to site II or the benzodiazepine site on HSA, although the drug also has a low affinity for site I. Circular dichroism (CD) spectra of PA bound to HSA in low drug to HSA and high drug to HSA ratios were completely different, indicating that the extrinsic mechanism responsible for the high and low affinity of PA
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