bacteriostatic activities with membrane blebbing, while ursolic acid showed bactericidal activity with membrane rupture. In particular, ursolic acid demonstrated a greater ability to affect bacterial membrane potential with increased membrane permeability, probably because of its highly lipophilic nature as compared with other compounds. Taken together, these findings provide mechanistic insight into the antibacterial activities of EEP and its exquisite membrane-targeting antibacterial compounds and imply the applicability of narrow-spectrum therapeutics with EEP for treatment of periodontitis. In addition, the advanced technology utilized in the present study to visualize the nanometer-scale dynamics of microorganisms will contribute to expanding our understanding of the activities of antimicrobials and the mechanism of drug resistance in bacteria. Supramolecular pharmaceutical sciences: A novel concept combining pharmaceutical sciences and supramolecular chemistry with a focus on cyclodextrin-based supermoleculesT. HigashiD. IoharaK. MotoyamaH. ArimaChem. Pharm. Bull.Vol. 66, pp.207-216201830 DOI: 10.1248/cpb.c17-00765 Supramolecular chemistry is an extremely useful and important domain for understanding pharmaceutical sciences because various physiological reactions and drug activities are based on supramolecular chemistry. In this review, we propose a new concept in pharmaceutical sciences termed "supramolecular pharmaceutical sciences," which combines pharmaceutical sciences and supramolecular chemistry. Glucose responsive rheological change and drug release from a novel worm-like micelle gel formed in cetyltrimethylammonium bromide/ phenylboronic acid/water system R. Miki
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