Surface-deacetylated Chitin Nanofibers Reinforced with a Sulfobutyl Ether β-Cyclodextrin Gel Loaded with Prednisolone as Potential Therapy for Inflammatory Bowel Disease R. Tabuchi M. Anraku D. Iohara T. Ishiguro S. Ifuku T. Nagae K. Uekama S. Okazaki K. Takeshita M. Otagiri F. Hirayama Carbohyd. Polym., Vol.174, pp.1087-1094 201729 DOI: 10.1016/j.carbpol.2017.07.028 Surface-deacetylated chitin nanofibers (SDACNFs) reinforced with a sulfobutyl ether β-cyclodextrin (SBE--CD) (NFs-CDs) gel were developed to obtain a controlled release carrier of prednisolone (PD) for the treatment of colitis. We evaluated the therapeutic effects of the NFs-CDs gel containing PD on dextran sulfate sodium (DSS)-induced colitis model mice. The administration of the NFs-CDs gel at intervals of 3 days from the beginning of the DSS treatment resulted in a significant improvement, not only in colitis symptoms but also histopathological changes in colon tissue. In addition, the therapeutic effects of the NFs-CDs gel on colitis can be attributed to decreased levels of neutrophil infiltration and the development of oxidative stress. A new resin glycoside from Calystegia soldanella and its antiviral activity towards herpes Masateru Ono Yukiyo Kanemaru
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