F. Hirayama Mol. Pharmaceutics, Vol.14, pp.2740-2748 201729 DOI: 10.1021/acs.molpharmaceut.7b00291 We report herein on the preparation of thermoresponsive hydrogels by taking advantage of the interaction of cyclodextrins (CDs) and a hydrophobically modified polymer. A hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC) gel formed thermoresponsive hydrogels when small amounts of α-CD were added to the solution. The HM-HPMC/α-CD showed reversible sol–gel transition in the physiological temperature range. The use of HM-HPMC/α-CD significantly improved the ocular absorption of a drug, diclofenac sodium, by virtue of the rapid formation of a gel on the ocular surface. Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin. Yamasaki K () Enokida T () Taguchi K () Miyamura S () Kawai A () Miyamoto S () Maruyama T () Seo H () Otagiri M () J Pharm Sci., Vol.106(9), pp.2860-2867 2017 (29) doi: 10.1016/j.xphs.2017.04.025 Sodium 4-phenylbutyrate (PB) is clinically used as a drug for treating urea cycle disorders. Recent research has shown that PB also has other pharmacologic activities, suggesting that it has the potential for use as a drug for treating other disorders. In the process of drug development, preclinical testing using experimental animals is necessary to verify the efficacy and safety of PB. Although the binding of PB to human albumin has been studied, our knowledge of its binding to albumin from the other animal species is extremely limited. To address this issue, we characterized the binding of PB to albumin
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