expression of caspase-3 appeared to overlap with the hypoxic zone of tumor tissues. Similar results were also obtained when the expts. were repeated using Epimedium ext., a natural herbal supplement with PDE5 inhibition activity. In conclusion, Poly-SNO-HSA/PDE5 inhibitors combination therapy is a promising approach for enhancing the anticancer therapeutic effects of Poly-SNO-HSA against not only anti-cancer drug resistance but also hypoxic stress related solid tumor resistance. Atypical cyclic sulfides, garlicnins G, I, and J, extracted from Allium sativum. Chem. Pharm. Bull.Vol. 65, pp. 102-106DOI: 10.1248/cpb.c16-00648 Newly characterized, atypical sulfides, garlicnins G (1), I (2), and J (3), were isolated from the acetone exts. of garlic bulbs, Allium sativum. Their prodn. pathways are regarded as different from those of cyclic sulfoxides, 3,4-dimethyltetrahydrothiophene-S-oxide derivs. such as onionins A1-A3, garlicnins B1-B4, and C1-C3. Antitumor Allium sulfides
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